IL18R1

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Interleukin 18 receptor 1
Identifiers
Symbol(s) IL18R1; CDw218a; IL-1Rrp; IL1RRP
External IDs OMIM: 604494 MGI: 105383 HomoloGene: 2861
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
Uniprot Q13478 Q8C257
Refseq NM_003855 (mRNA)
NP_003846 (protein)		 NM_008365 (mRNA)
NP_032391 (protein)
Location Chr 2: 102.35 - 102.38 Mb Chr 1: 40.41 - 40.45 Mb
Pubmed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: IL18R1 interleukin 18 receptor 1.

[edit] Further reading

  • Sergi B, Penttila I (2005). "Interleukin 18 receptor.". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361. 
  • Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.". J. Biol. Chem. 271 (8): 3967–70. PMID 8626725. 
  • Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).". J. Neuroimmunol. 70 (2): 113–22. PMID 8898719. 
  • Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. PMID 9325300. 
  • Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101. 
  • Hoshino K, Tsutsui H, Kawai T, et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.". J. Immunol. 162 (9): 5041–4. PMID 10227969. 
  • Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.". J. Immunol. 165 (4): 1933–8. PMID 10925275. 
  • Kumar S, Hanning CR, Brigham-Burke MR, et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.". Cytokine 18 (2): 61–71. PMID 12096920. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gutzmer R, Langer K, Mommert S, et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18.". J. Immunol. 171 (12): 6363–71. PMID 14662834. 
  • Azam T, Novick D, Bufler P, et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.". J. Immunol. 171 (12): 6574–80. PMID 14662859. 
  • Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551. 
  • Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha.". Eur. J. Immunogenet. 31 (1): 27–9. PMID 15009178. 
  • Reddy SA, Lin YF, Huang HJ, et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation.". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087. 
  • Yoon- DY, Cho YS, Park JW, et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor.". Clin. Chem. Lab. Med. 42 (5): 499–506. PMID 15202785. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Sahar S, Dwarakanath RS, Reddy MA, et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis.". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756. 

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
v • d • e
Transmembrane receptors: immune receptors
Cytokine receptor
Pattern recognition/Toll-like
Fc receptor
Lymphocyte homing receptor
other