CD37
From Wikipedia, the free encyclopedia
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CD37 molecule
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| Identifiers | |||||||||||
| Symbol(s) | CD37; GP52-40; MGC120234; TSPAN26 | ||||||||||
| External IDs | OMIM: 151523 MGI: 88330 HomoloGene: 20422 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 951 | 12493 | |||||||||
| Ensembl | ENSG00000104894 | ENSMUSG00000030798 | |||||||||
| Uniprot | P11049 | Q3U1W9 | |||||||||
| Refseq | NM_001040031 (mRNA) NP_001035120 (protein) |
NM_007645 (mRNA) NP_031671 (protein) |
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| Location | Chr 19: 54.53 - 54.54 Mb | Chr 7: 45.1 - 45.11 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
CD37, also known as Cluster of Differentiation 37, is a human gene.[1]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63.". FEBS Lett. 288 (1-2): 1–4. PMID 1879540.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Classon BJ, Williams AF, Willis AC, et al. (1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.". J. Exp. Med. 172 (3): 1007. PMID 2388030.
- Classon BJ, Williams AF, Willis AC, et al. (1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.". J. Exp. Med. 169 (4): 1497–502. PMID 2466944.
- Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein.". J. Immunol. 140 (3): 905–14. PMID 3257508.
- Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins.". Immunogenetics 39 (4): 249–56. PMID 8119731.
- Virtaneva KI, Angelisová P, Baumruker T, et al. (1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes.". Immunogenetics 37 (6): 461–5. PMID 8436422.
- Wright MD, Rochelle JM, Tomlinson MG, et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication.". Int. Immunol. 5 (2): 209–16. PMID 8452817.
- Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 ( Pt 1): 103–11. PMID 10229664.
- Okochi H, Mine T, Nashiro K, et al. (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract.". J. Clin. Gastroenterol. 29 (1): 63–7. PMID 10405235.
- Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils.". Int. Arch. Allergy Immunol. 120 Suppl 1: 38–44. PMID 10529602.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- van Spriel AB, Puls KL, Sofi M, et al. (2004). "A regulatory role for CD37 in T cell proliferation.". J. Immunol. 172 (5): 2953–61. PMID 14978098.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Meyer-Wentrup F, Figdor CG, Ansems M, et al. (2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production.". J. Immunol. 178 (1): 154–62. PMID 17182550.
- Zhao X, Lapalombella R, Joshi T, et al. (2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical.". Blood 110 (7): 2569–77. doi:. PMID 17440052.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
