MSR1
From Wikipedia, the free encyclopedia
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Macrophage scavenger receptor 1
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| Identifiers | ||||||||||||||
| Symbol(s) | MSR1; CD204; SCARA1; SR-A; phSR1; phSR2 | |||||||||||||
| External IDs | OMIM: 153622 MGI: 98257 HomoloGene: 12822 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4481 | 20288 | ||||||||||||
| Ensembl | ENSG00000038945 | ENSMUSG00000025044 | ||||||||||||
| Uniprot | P21757 | Q3U2C3 | ||||||||||||
| Refseq | NM_002445 (mRNA) NP_002436 (protein) |
NM_031195 (mRNA) NP_112472 (protein) |
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| Location | Chr 8: 16.01 - 16.09 Mb | Chr 8: 41.08 - 41.13 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Macrophage scavenger receptor 1, also known as MSR1, is a human gene.[1]
MSR1 has also recently been designated CD204 (cluster of differentiation 204).
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.[1]
[edit] References
[edit] Further reading
- Asaoka H, Matsumoto A, Itakura H, Kodama T (1993). "[Structural and function of the human macrophage scavenger receptor]". Nippon Rinsho 51 (6): 1677–83. PMID 8391600.
- Naito M, Suzuki H, Mori T, et al. (1992). "Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions.". Am. J. Pathol. 141 (3): 591–9. PMID 1519666.
- Matsumoto A, Naito M, Itakura H, et al. (1991). "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9133–7. PMID 2251254.
- Emi M, Asaoka H, Matsumoto A, et al. (1993). "Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene.". J. Biol. Chem. 268 (3): 2120–5. PMID 8093617.
- Ashkenas J, Penman M, Vasile E, et al. (1993). "Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors.". J. Lipid Res. 34 (6): 983–1000. PMID 8394868.
- Resnick D, Chatterton JE, Schwartz K, et al. (1996). "Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain.". J. Biol. Chem. 271 (43): 26924–30. PMID 8900177.
- Hsu HY, Hajjar DP, Khan KM, Falcone DJ (1998). "Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway.". J. Biol. Chem. 273 (2): 1240–6. PMID 9422792.
- Gough PJ, Greaves DR, Gordon S (1998). "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake.". J. Lipid Res. 39 (3): 531–43. PMID 9548586.
- Teupser D, Thiery J, Seidel D (1999). "Alpha-tocopherol down-regulates scavenger receptor activity in macrophages.". Atherosclerosis 144 (1): 109–15. PMID 10381284.
- Nakamura T, Hinagata J, Tanaka T, et al. (2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors.". Biochem. Biophys. Res. Commun. 290 (2): 858–64. doi:. PMID 11785981.
- Tomokiyo R, Jinnouchi K, Honda M, et al. (2002). "Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.". Atherosclerosis 161 (1): 123–32. PMID 11882324.
- Xu J, Zheng SL, Komiya A, et al. (2002). "Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.". Nat. Genet. 32 (2): 321–5. doi:. PMID 12244320.
- Xu J, Zheng SL, Komiya A, et al. (2003). "Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.". Am. J. Hum. Genet. 72 (1): 208–12. PMID 12471593.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Kosswig N, Rice S, Daugherty A, Post SR (2003). "Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains.". J. Biol. Chem. 278 (36): 34219–25. doi:. PMID 12819208.
- Miller DC, Zheng SL, Dunn RL, et al. (2003). "Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.". Cancer Res. 63 (13): 3486–9. PMID 12839931.
- Wang L, McDonnell SK, Cunningham JM, et al. (2003). "No association of germline alteration of MSR1 with prostate cancer risk.". Nat. Genet. 35 (2): 128–9. doi:. PMID 12958598.
- Nupponen NN, Wallén MJ, Ponciano D, et al. (2004). "Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer.". Genes Chromosomes Cancer 39 (2): 119–25. doi:. PMID 14695991.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:. PMID 14759258.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
