SIRPB1
From Wikipedia, the free encyclopedia
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Signal-regulatory protein beta 1
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| PDB rendering based on 2d9c. | |||||||||||
| Available structures: 2d9c | |||||||||||
| Identifiers | |||||||||||
| Symbol(s) | SIRPB1; CD172b; DKFZp686A05192; SIRP-BETA-1 | ||||||||||
| External IDs | OMIM: 603889 HomoloGene: 88736 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 10326 | n/a | |||||||||
| Ensembl | ENSG00000101307 | n/a | |||||||||
| Uniprot | O00241 | n/a | |||||||||
| Refseq | NM_006065 (mRNA) NP_006056 (protein) |
n/a (mRNA) n/a (protein) |
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| Location | Chr 20: 1.49 - 1.55 Mb | n/a | |||||||||
| Pubmed search | [1] | n/a | |||||||||
Signal-regulatory protein beta 1, also known as SIRPB1, is a human gene.[1] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[1]
[edit] References
[edit] Further reading
- Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors.". Nature 386 (6621): 181–6. doi:. PMID 9062191.
- Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.". J. Immunol. 164 (1): 9–12. PMID 10604985.
- Tomasello E, Cant C, Bühring HJ, et al. (2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12.". Eur. J. Immunol. 30 (8): 2147–56. PMID 10940905.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:. PMID 11780052.
- Cannon JP, Haire RN, Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.". Nat. Immunol. 3 (12): 1200–7. doi:. PMID 12415263.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration.". J. Biol. Chem. 280 (43): 36132–40. doi:. PMID 16081415.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:. PMID 16335952.
- van den Berg TK, van Beek EM, Bühring HJ, et al. (2006). "A nomenclature for signal regulatory protein family members.". J. Immunol. 175 (12): 7788–9. PMID 16339511.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
