CD49b

From Wikipedia, the free encyclopedia

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
PDB rendering based on 1aox.
Available structures: 1aox, 1dzi, 1v7p
Identifiers
Symbol(s)	ITGA2; BR; CD49B; GPIa; VLA-2; VLAA2
External IDs	OMIM: 192974 MGI: 96600 HomoloGene: 1662
Gene ontology Molecular Function: • magnesium ion binding • receptor activity • calcium ion binding • collagen binding • identical protein binding Cellular Component: • plasma membrane • integrin complex • integral to membrane Biological Process: • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • blood coagulation • organ morphogenesis
Orthologs
	Human	Mouse
Entrez	3673	16398
Ensembl	ENSG00000164171	ENSMUSG00000015533
Uniprot	P17301	Q6P1C7
Refseq	NM_002203 (mRNA) NP_002194 (protein)	XM_982915 (mRNA) XP_988009 (protein)
Location	Chr 5: 52.32 - 52.42 Mb	Chr 13: 115.96 - 116.05 Mb
Pubmed search	[1]	[2]

CD49b (also known as DX5) is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex.

This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.^[1]

[edit] External links

• MeSH CD49b+antigen

[edit] References

[edit] Further reading

This immunology article is a stub. You can help Wikipedia by expanding it.