Decay accelerating factor

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CD55 molecule, decay accelerating factor for complement (Cromer blood group)
PDB rendering based on 1h03.
Available structures: 1h03, 1h04, 1h2p, 1h2q, 1m11, 1nwv, 1ojv, 1ojw, 1ojy, 1ok1, 1ok2, 1ok3, 1ok9, 1uot, 1upn, 2c8i
Identifiers
Symbol(s)	CD55; CR; DAF; TC
External IDs	OMIM: 125240 MGI: 104850 HomoloGene: 479
Gene ontology Molecular Function: • GPI anchor binding Cellular Component: • soluble fraction • integral to plasma membrane • membrane Biological Process: • complement activation, classical pathway • innate immune response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1604	13136
Ensembl	ENSG00000196352	ENSMUSG00000026399
Uniprot	P08174	Q3TU32
Refseq	NM_000574 (mRNA) NP_000565 (protein)	NM_010016 (mRNA) NP_034146 (protein)
Location	Chr 1: 205.56 - 205.6 Mb	Chr 1: 132.27 - 132.29 Mb
Pubmed search	[1]	[2]

Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

[edit] Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

[edit] See also

• List of human clusters of differentiation

[edit] Further reading

[edit] External links

• MeSH Decay-Accelerating+Factor
• Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH

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