CD74

From Wikipedia, the free encyclopedia


CD74 molecule, major histocompatibility complex, class II invariant chain
PDB rendering based on 1icf.
Available structures: 1icf, 1iie, 1l3h
Identifiers
Symbol(s) CD74; DHLAG; HLADG; Ia-GAMMA; protein 41
External IDs OMIM: 142790 MGI: 96534 HomoloGene: 3209
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 972 16149
Ensembl ENSG00000019582 ENSMUSG00000024610
Uniprot P04233 Q3U4Q8
Refseq NM_001025158 (mRNA)
NP_001020329 (protein)		 NM_001042605 (mRNA)
NP_001036070 (protein)
Location Chr 5: 149.76 - 149.77 Mb Chr 18: 60.93 - 60.95 Mb
Pubmed search [1] [2]

CD74 molecule, major histocompatibility complex, class II invariant chain, also known as CD74 (Cluster of Differentiation 74), is a human gene.


[edit] See also

[edit] Further reading

  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711. 
  • Riberdy JM, Newcomb JR, Surman MJ, et al. (1992). "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.". Nature 360 (6403): 474–7. doi:10.1038/360474a0. PMID 1448172. 
  • Bakke O, Dobberstein B (1990). "MHC class II-associated invariant chain contains a sorting signal for endosomal compartments.". Cell 63 (4): 707–16. PMID 2121367. 
  • Marks MS, Blum JS, Cresswell P (1990). "Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.". J. Cell Biol. 111 (3): 839–55. PMID 2391366. 
  • Spiro RC, Quaranta V (1989). "The invariant chain is a phosphorylated subunit of class II molecules.". J. Immunol. 143 (8): 2589–94. PMID 2507633. 
  • Kudo J, Chao LY, Narni F, Saunders GF (1986). "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.". Nucleic Acids Res. 13 (24): 8827–41. PMID 3001652. 
  • O'Sullivan DM, Noonan D, Quaranta V (1987). "Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation.". J. Exp. Med. 166 (2): 444–60. PMID 3036998. 
  • Genuardi M, Saunders GF (1988). "Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32.". Immunogenetics 28 (1): 53–6. PMID 3132422. 
  • O'Sullivan DM, Larhammar D, Wilson MC, et al. (1986). "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes.". Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4484–8. PMID 3459184. 
  • Koch N, Hämmerling GJ (1986). "Ia-associated invariant chain is fatty acylated before addition of sialic acid.". Biochemistry 24 (22): 6185–90. PMID 3866610. 
  • Claesson L, Larhammar D, Rask L, Peterson PA (1984). "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.". Proc. Natl. Acad. Sci. U.S.A. 80 (24): 7395–9. PMID 6324166. 
  • Claesson L, Peterson PA (1983). "Association of human gamma chain with class II transplantation antigens during intracellular transport.". Biochemistry 22 (13): 3206–13. PMID 6576808. 
  • Strubin M, Mach B, Long EO (1984). "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.". EMBO J. 3 (4): 869–72. PMID 6586420. 
  • Kvist S, Wiman K, Claesson L, et al. (1982). "Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens.". Cell 29 (1): 61–9. PMID 6955026. 
  • Machamer CE, Cresswell P (1983). "Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.". J. Immunol. 129 (6): 2564–9. PMID 6982931. 
  • Ghosh P, Amaya M, Mellins E, Wiley DC (1995). "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.". Nature 378 (6556): 457–62. doi:10.1038/378457a0. PMID 7477400. 
  • Bijlmakers MJ, Benaroch P, Ploegh HL (1994). "Mapping functional regions in the lumenal domain of the class II-associated invariant chain.". J. Exp. Med. 180 (2): 623–9. PMID 7519244. 
  • Brown JH, Jardetzky TS, Gorga JC, et al. (1993). "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.". Nature 364 (6432): 33–9. doi:10.1038/364033a0. PMID 8316295. 
  • Naujokas MF, Morin M, Anderson MS, et al. (1993). "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.". Cell 74 (2): 257–68. PMID 8343954. 
  • Roche PA, Teletski CL, Stang E, et al. (1993). "Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.". Proc. Natl. Acad. Sci. U.S.A. 90 (18): 8581–5. PMID 8397411. 

[edit] External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350