Hyaluronan-mediated motility receptor
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Hyaluronan-mediated motility receptor (RHAMM)
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| Identifiers | |||||||||||
| Symbol(s) | HMMR; CD168; IHABP; MGC119494; MGC119495; RHAMM | ||||||||||
| External IDs | OMIM: 600936 MGI: 104667 HomoloGene: 8271 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 3161 | 15366 | |||||||||
| Ensembl | ENSG00000072571 | ENSMUSG00000020330 | |||||||||
| Uniprot | O75330 | Q3TP93 | |||||||||
| Refseq | NM_012484 (mRNA) NP_036616 (protein) |
NM_013552 (mRNA) NP_038580 (protein) |
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| Location | Chr 5: 162.82 - 162.85 Mb | Chr 11: 40.55 - 40.58 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Hyaluronan-mediated motility receptor (RHAMM), also known as HMMR, is a human gene.[1] RHAMM recently has been designated CD168 (cluster of differentiation 168).
The receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts. In human, it is expressed as an intracellular protein in breast cancer cells. No correlation between the level of HMMR mRNA and protein expression with known metastatic/malignant potential of the tumour cell lines was observed.[1]
[edit] References
[edit] Further reading
- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317-20. PMID 1602151.
- Hall CL, Yang B, Yang X, et al. (1995). "Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation.". Cell 82 (1): 19-26. PMID 7541721.
- Pilarski LM, Miszta H, Turley EA (1993). "Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells.". J. Immunol. 150 (10): 4292-302. PMID 7683315.
- Spicer AP, Roller ML, Camper SA, et al. (1996). "The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11.". Genomics 30 (1): 115-7. doi:. PMID 8595891.
- Wang C, Entwistle J, Hou G, et al. (1996). "The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.". Gene 174 (2): 299-306. PMID 8890751.
- Assmann V, Marshall JF, Fieber C, et al. (1999). "The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.". J. Cell. Sci. 111 ( Pt 12): 1685-94. PMID 9601098.
- Pilarski LM, Pruski E, Wizniak J, et al. (1999). "Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells.". Blood 93 (9): 2918-27. PMID 10216086.
- Assmann V, Jenkinson D, Marshall JF, Hart IR (2000). "The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments.". J. Cell. Sci. 112 ( Pt 22): 3943-54. PMID 10547355.
- Lokeshwar VB, Selzer MG (2000). "Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells.". J. Biol. Chem. 275 (36): 27641-9. doi:. PMID 10882722.
- Lynn BD, Li X, Cattini PA, Nagy JI (2001). "Sequence, protein expression and extracellular-regulated kinase association of the hyaladherin RHAMM (receptor for hyaluronan mediated motility) in PC12 cells.". Neurosci. Lett. 306 (1-2): 49-52. PMID 11403955.
- Lynn BD, Turley EA, Nagy JI (2001). "Subcellular distribution, calmodulin interaction, and mitochondrial association of the hyaluronan-binding protein RHAMM in rat brain.". J. Neurosci. Res. 65 (1): 6-16. PMID 11433424.
- Savani RC, Cao G, Pooler PM, et al. (2001). "Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis.". J. Biol. Chem. 276 (39): 36770-8. doi:. PMID 11448954.
- Akiyama Y, Jung S, Salhia B, et al. (2002). "Hyaluronate receptors mediating glioma cell migration and proliferation.". J. Neurooncol. 53 (2): 115-27. PMID 11716065.
- Greiner J, Ringhoffer M, Taniguchi M, et al. (2002). "Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia.". Exp. Hematol. 30 (9): 1029-35. PMID 12225794.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Rein DT, Roehrig K, Schöndorf T, et al. (2003). "Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis.". J. Cancer Res. Clin. Oncol. 129 (3): 161-4. doi:. PMID 12712331.
- Maxwell CA, Keats JJ, Crainie M, et al. (2004). "RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability.". Mol. Biol. Cell 14 (6): 2262-76. doi:. PMID 12808028.
- Aziz KA (2004). "CD44 mediates polymorphonuclear leukocyte motility on hyaluronan.". Saudi medical journal 24 (8): 827-31. PMID 12939665.
- Maxwell CA, Keats JJ, Belch AR, et al. (2005). "Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity.". Cancer Res. 65 (3): 850-60. PMID 15705883.
- Yamasaki C, Tashiro S, Nishito Y, et al. (2005). "Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP.". J. Biochem. 137 (3): 287-96. doi:. PMID 15809329.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
