CD18

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Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
PDB rendering based on 1l3y.
Available structures: 1l3y, 1yuk
Identifiers
Symbol(s)	ITGB2; LAD; LFA-1; MAC-1; CD18; LCAMB; MF17; MFI7
External IDs	OMIM: 600065 MGI: 96611 HomoloGene: 20092
Gene ontology Molecular Function: • receptor activity • protein binding • protein kinase binding Cellular Component: • integrin complex • membrane • integral to membrane Biological Process: • apoptosis • inflammatory response • cell adhesion • leukocyte adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • cell-cell signaling • multicellular organismal development • regulation of cell shape • antimicrobial humoral response • neutrophil chemotaxis • regulation of peptidyl-tyrosine phosphorylation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
Uniprot	P05107	Q542I8
Refseq	NM_000211 (mRNA) NP_000202 (protein)	NM_008404 (mRNA) NP_032430 (protein)
Location	Chr 21: 45.13 - 45.17 Mb	Chr 10: 76.99 - 77.01 Mb
Pubmed search	[1]	[2]

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), also known as CD18 or ITGB2, is a human gene.

CD18 is the beta subunit of three different structures:

• LFA-1 (paired with CD11a)
• Macrophage-1 antigen (paired with CD11b)
• Integrin alphaXbeta2 (paired with CD11c)

The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.^[1]

[edit] References

[edit] Further reading

[edit] See also

• leukocyte adhesion deficiency
• integrin

[edit] External links

• MeSH CD18+antigen

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