LFA-1

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LFA-1 stands for Lymphocyte function-associated antigen-1.

LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.

LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).

[edit] See also

• Leukocyte adhesion deficiency

[edit] Further reading

• Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY

[edit] External links

• MeSH LFA-1
• Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMID 7027264. 

v • d • e Transmembrane receptors: immune receptors Cytokine receptor Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2) Pattern recognition/Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger

v • d • e Membrane proteins: cell adhesion molecules IgSF N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM Cadherins Desmoglein - T-cadherin - protocadherin Selectins E-selectin - L-selectin - P-selectin Integrins LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs) Other Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164