Lymphotoxin beta receptor

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Lymphotoxin beta receptor (TNFR superfamily, member 3)
Identifiers
Symbol(s) LTBR; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
External IDs OMIM: 600979 MGI: 104875 HomoloGene: 1753
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4055 17000
Ensembl ENSG00000111321 n/a
Uniprot P36941 n/a
Refseq NM_002342 (mRNA)
NP_002333 (protein)		 XM_982227 (mRNA)
XP_987321 (protein)
Location Chr 12: 6.36 - 6.37 Mb n/a
Pubmed search [1] [2]

Lymphotoxin beta receptor is a receptor for lymphotoxin.

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.[1]

[edit] References

  1. ^ Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3).

[edit] Further reading

  • Elewaut D, Ware CF (2007). "The unconventional role of LT alpha beta in T cell differentiation.". Trends Immunol. 28 (4): 169–75. doi:10.1016/j.it.2007.02.005. PMID 17336158. 
  • Browning JL, Ngam-ek A, Lawton P, et al. (1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.". Cell 72 (6): 847–56. PMID 7916655. 
  • Crowe PD, VanArsdale TL, Walter BN, et al. (1994). "A lymphotoxin-beta-specific receptor.". Science 264 (5159): 707–10. PMID 8171323. 
  • Baens M, Chaffanet M, Cassiman JJ, et al. (1993). "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.". Genomics 16 (1): 214–8. doi:10.1006/geno.1993.1161. PMID 8486360. 
  • Baens M, Aerssens J, van Zand K, et al. (1996). "Isolation and regional assignment of human chromosome 12p cDNAs.". Genomics 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100. 
  • Wang X, Bornslaeger EA, Haub O, et al. (1996). "A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.". Dev. Biol. 177 (1): 274–90. doi:10.1006/dbio.1996.0162. PMID 8660894. 
  • Nakano H, Oshima H, Chung W, et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.". J. Biol. Chem. 271 (25): 14661–4. PMID 8663299. 
  • Matsumoto M, Hsieh TY, Zhu N, et al. (1997). "Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.". J. Virol. 71 (2): 1301–9. PMID 8995654. 
  • VanArsdale TL, VanArsdale SL, Force WR, et al. (1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. PMID 9122217. 
  • Wu MY, Hsu TL, Lin WW, et al. (1997). "Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells.". J. Biol. Chem. 272 (27): 17154–9. PMID 9202035. 
  • Chen CM, You LR, Hwang LH, Lee YH (1997). "Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor.". J. Virol. 71 (12): 9417–26. PMID 9371602. 
  • Mizushima S, Fujita M, Ishida T, et al. (1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).". Gene 207 (2): 135–40. PMID 9511754. 
  • Krajewska M, Krajewski S, Zapata JM, et al. (1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.". Am. J. Pathol. 152 (6): 1549–61. PMID 9626059. 
  • Boussaud V, Soler P, Moreau J, et al. (1999). "Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung.". Eur. Respir. J. 12 (4): 926–31. PMID 9817170. 
  • Murphy M, Walter BN, Pike-Nobile L, et al. (1999). "Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.". Cell Death Differ. 5 (6): 497–505. doi:10.1038/sj.cdd.4400374. PMID 10200501. 
  • Wu MY, Wang PY, Han SH, Hsieh SL (1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.". J. Biol. Chem. 274 (17): 11868–73. PMID 10207006. 
  • Yu KY, Kwon B, Ni J, et al. (1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.". J. Biol. Chem. 274 (20): 13733–6. PMID 10318773. 
  • Rooney IA, Butrovich KD, Glass AA, et al. (2000). "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.". J. Biol. Chem. 275 (19): 14307–15. PMID 10799510. 
  • Langeggen H, Berge KE, Johnson E, Hetland G (2003). "Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro.". Inflammation 26 (3): 103–10. PMID 12083416. 
  • Chang YH, Hsieh SL, Chen MC, Lin WW (2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.". Exp. Cell Res. 278 (2): 166–74. PMID 12169272. 

[edit] External links

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