TNFRSF18

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Tumor necrosis factor receptor superfamily, member 18
Identifiers
Symbol(s) TNFRSF18; AITR; GITR; GITR-D
External IDs OMIM: 603905 MGI: 894675 HomoloGene: 48270
Orthologs
Human Mouse
Entrez 8784 21936
Ensembl ENSG00000186891 ENSMUSG00000041954
Uniprot Q9Y5U5 Q540M6
Refseq NM_004195 (mRNA)
NP_004186 (protein)		 NM_009400 (mRNA)
NP_033426 (protein)
Location Chr 1: 1.13 - 1.13 Mb Chr 4: 154.87 - 154.87 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 18, also known as TNFRSF18, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF18 tumor necrosis factor receptor superfamily, member 18.

[edit] Further reading

  • Nocentini G, Giunchi L, Ronchetti S, et al. (1997). "A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6216–21. PMID 9177197. 
  • Kwon B, Yu KY, Ni J, et al. (1999). "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.". J. Biol. Chem. 274 (10): 6056–61. PMID 10037686. 
  • Gurney AL, Marsters SA, Huang RM, et al. (1999). "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.". Curr. Biol. 9 (4): 215–8. PMID 10074428. 
  • Nocentini G, Ronchetti S, Bartoli A, et al. (2000). "Identification of three novel mRNA splice variants of GITR.". Cell Death Differ. 7 (4): 408–10. doi:10.1038/sj.cdd.4400670. PMID 10836847. 
  • Shimizu J, Yamazaki S, Takahashi T, et al. (2002). "Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.". Nat. Immunol. 3 (2): 135–42. doi:10.1038/ni759. PMID 11812990. 
  • McHugh RS, Whitters MJ, Piccirillo CA, et al. (2002). "CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.". Immunity 16 (2): 311–23. PMID 11869690. 
  • Ronchetti S, Nocentini G, Riccardi C, Pandolfi PP (2002). "Role of GITR in activation response of T lymphocytes.". Blood 100 (1): 350–2. doi:10.1182/blood-2001-12-0276. PMID 12070049. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Esparza EM, Arch RH (2005). "Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-kappa B activation.". J. Immunol. 174 (12): 7875–82. PMID 15944293. 
  • Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, et al. (2006). "Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis.". Acta Derm. Venereol. 86 (5): 393–8. doi:10.2340/00015555-0118. PMID 16955181. 
  • Baltz KM, Krusch M, Bringmann A, et al. (2007). "Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions.". FASEB J. 21 (10): 2442–54. doi:10.1096/fj.06-7724com. PMID 17360848. 
  • Lahey TP, Loisel SD, Wieland-Alter W (2007). "Glucocorticoid-induced tumor necrosis factor receptor family-related protein triggering enhances HIV-specific CD4+ T cell cytokine secretion and protects HIV-specific CD4+ T cells from apoptosis.". J. Infect. Dis. 196 (1): 43–9. doi:10.1086/518613. PMID 17538882. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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