CD137
From Wikipedia, the free encyclopedia
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Tumor necrosis factor receptor superfamily, member 9
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| Identifiers | ||||||||||||||
| Symbol(s) | TNFRSF9; 4-1BB; CD137; CDw137; ILA; MGC2172 | |||||||||||||
| External IDs | OMIM: 602250 MGI: 1101059 HomoloGene: 1199 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3604 | 21942 | ||||||||||||
| Ensembl | ENSG00000049249 | ENSMUSG00000028965 | ||||||||||||
| Uniprot | Q07011 | Q3U3R1 | ||||||||||||
| Refseq | NM_001561 (mRNA) NP_001552 (protein) |
NM_001077508 (mRNA) NP_001070976 (protein) |
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| Location | Chr 1: 7.9 - 7.92 Mb | Chr 4: 149.76 - 149.79 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).
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[edit] Expression
CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
[edit] Specific effects on cells
The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
[edit] See also
[edit] References
- Kwon BS, Weissman SM (1989). "cDNA sequences of two inducible T-cell genes". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1963–7. PMID 2784565.
- Schwarz H, Tuckwell J, Lotz M (1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family". Gene 134 (2): 295–8. PMID 8262389.
[edit] Further reading
- Sica G, Chen L (2000). "Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy.". Arch. Immunol. Ther. Exp. (Warsz.) 47 (5): 275–9. PMID 10604232.
- Schwarz H (2005). "Biological activities of reverse signal transduction through CD137 ligand.". J. Leukoc. Biol. 77 (3): 281–6. doi:. PMID 15618293.
- Kwon BS, Weissman SM (1989). "cDNA sequences of two inducible T-cell genes.". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1963–7. PMID 2784565.
- Zhou Z, Kim S, Hurtado J, et al. (1995). "Characterization of human homologue of 4-1BB and its ligand.". Immunol. Lett. 45 (1-2): 67–73. PMID 7622190.
- Alderson MR, Smith CA, Tough TW, et al. (1994). "Molecular and biological characterization of human 4-1BB and its ligand.". Eur. J. Immunol. 24 (9): 2219–27. PMID 8088337.
- Schwarz H, Tuckwell J, Lotz M (1994). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.". Gene 134 (2): 295–8. PMID 8262389.
- Schwarz H, Blanco FJ, von Kempis J, et al. (1996). "ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival.". Blood 87 (7): 2839–45. PMID 8639902.
- Loo DT, Chalupny NJ, Bajorath J, et al. (1997). "Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.". J. Biol. Chem. 272 (10): 6448–56. PMID 9045669.
- Schwarz H, Arden K, Lotz M (1997). "CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies.". Biochem. Biophys. Res. Commun. 235 (3): 699–703. doi:. PMID 9207223.
- Arch RH, Thompson CB (1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.". Mol. Cell. Biol. 18 (1): 558–65. PMID 9418902.
- Jang IK, Lee ZH, Kim YJ, et al. (1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B.". Biochem. Biophys. Res. Commun. 242 (3): 613–20. doi:. PMID 9464265.
- Kim YJ, Kim SH, Mantel P, Kwon BS (1998). "Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses.". Eur. J. Immunol. 28 (3): 881–90. PMID 9541583.
- Saoulli K, Lee SY, Cannons JL, et al. (1998). "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.". J. Exp. Med. 187 (11): 1849–62. PMID 9607925.
- Langstein J, Michel J, Schwarz H (1999). "CD137 induces proliferation and endomitosis in monocytes.". Blood 94 (9): 3161–8. PMID 10556203.
- Jang LK, Lee ZH, Kim HH, et al. (2002). "A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction.". Mol. Cells 12 (3): 304–12. PMID 11804328.
- Cooper D, Bansal-Pakala P, Croft M (2002). "4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity.". Eur. J. Immunol. 32 (2): 521–9. PMID 11828369.
- Wilcox RA, Chapoval AI, Gorski KS, et al. (2002). "Cutting edge: Expression of functional CD137 receptor by dendritic cells.". J. Immunol. 168 (9): 4262–7. PMID 11970964.
- Shulzhenko N, Morgun A, Chinellato AP, et al. (2002). "CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans.". Transplant. Proc. 34 (2): 474–5. PMID 12009595.
- Pauly S, Broll K, Wittmann M, et al. (2002). "CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers.". J. Leukoc. Biol. 72 (1): 35–42. PMID 12101260.
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