ITGAV
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Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
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| Available structures: 1jv2, 1l5g, 1m1x, 1u8c | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ITGAV; CD51; MSK8; VNRA | |||||||||||||
| External IDs | OMIM: 193210 MGI: 96608 HomoloGene: 20510 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3685 | 16410 | ||||||||||||
| Ensembl | ENSG00000138448 | ENSMUSG00000027087 | ||||||||||||
| Uniprot | P06756 | Q3U4C8 | ||||||||||||
| Refseq | NM_002210 (mRNA) NP_002201 (protein) |
NM_008402 (mRNA) NP_032428 (protein) |
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| Location | Chr 2: 187.16 - 187.25 Mb | Chr 2: 83.53 - 83.6 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), also known as ITGAV, is a human gene.
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. PMID 9251239.
- Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. PMID 9789327.
- Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
- Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia 4 (3): 191–4. doi:. PMID 11988838.
- Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.
[edit] External links
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