CD7

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CD7 molecule
Identifiers
Symbol(s) CD7; GP40; LEU-9; TP41; Tp40
External IDs OMIM: 186820 MGI: 88344 HomoloGene: 4471
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 924 12516
Ensembl ENSG00000173762 ENSMUSG00000025163
Uniprot P09564 Q3U4A8
Refseq NM_006137 (mRNA)
NP_006128 (protein)		 NM_009854 (mRNA)
NP_033984 (protein)
Location Chr 17: 77.87 - 77.87 Mb Chr 11: 120.85 - 120.86 Mb
Pubmed search [1] [2]

CD7 (Cluster of Differentiation 7) is a human protein encoded by the CD7 gene.[1]

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CD7 CD7 molecule.

[edit] Further reading

  • Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation.". Immunol. Res. 24 (1): 31-52. PMID 11485208. 
  • Baker E, Sandrin MS, Garson OM, et al. (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization.". Immunogenetics 31 (5-6): 412-3. PMID 1695199. 
  • Schanberg LE, Fleenor DE, Kurtzberg J, et al. (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603-7. PMID 1703303. 
  • Yoshikawa K, Seto M, Ueda R, et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.". Immunogenetics 33 (5-6): 352-60. PMID 1711009. 
  • Ware RE, Scearce RM, Dietz MA, et al. (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.". J. Immunol. 143 (11): 3632-40. PMID 2479685. 
  • Osada S, Utsumi KR, Ueda R, et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.". Cytogenet. Cell Genet. 47 (1-2): 8-10. PMID 3258561. 
  • Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.". EMBO J. 6 (11): 3313-6. PMID 3501369. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Lee DM, Schanberg LE, Fleenor DE, et al. (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.". Immunogenetics 44 (2): 108-14. PMID 8662072. 
  • Bevec T, Stoka V, Pungercic G, et al. (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331-8. PMID 8666891. 
  • Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7.". Cell. Immunol. 173 (1): 15-21. doi:10.1006/cimm.1996.0247. PMID 8871597. 
  • Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.". Int. Immunol. 8 (8): 1195-203. PMID 8918688. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327-40. doi:10.1006/geno.1997.5151. PMID 9480746. 
  • Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171-9. PMID 9852078. 
  • Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801-11. PMID 10490978. 
  • Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431-7. PMID 10652336. 
  • Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054-60. doi:10.1074/jbc.M009913200. PMID 11423532. 
  • Rossi MI, Yokota T, Medina KL, et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes.". Blood 101 (2): 576-84. doi:10.1182/blood-2002-03-0896. PMID 12393702. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
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