B-cell activating factor

From Wikipedia, the free encyclopedia

Tumor necrosis factor (ligand) superfamily, member 13b
PDB rendering based on 1jh5.
Available structures: 1jh5, 1kd7, 1kxg, 1oqd, 1oqe, 1osg, 1otz
Identifiers
Symbol(s) TNFSF13B; BAFF; BLYS; CD257; TALL-1; TALL1; THANK; TNFSF20; ZTNF4; delta BAFF
External IDs OMIM: 603969 MGI: 1344376 HomoloGene: 48443
Orthologs
Human Mouse
Entrez 10673 24099
Ensembl ENSG00000102524 ENSMUSG00000031497
Uniprot Q9Y275 Q3KP92
Refseq NM_006573 (mRNA)
NP_006564 (protein)		 NM_033622 (mRNA)
NP_296371 (protein)
Location Chr 13: 107.72 - 107.76 Mb Chr 8: 10.01 - 10.04 Mb
Pubmed search [1] [2]

B-cell activating factor (BAFF) is the tumor necrosis factor ligand superfamily member 13B (TNFLSF13B), also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257).

BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called A Proliferation Inducing Ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling trough BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors.[1]

[edit] References

  1. ^ Oren,D.A., Li,Y., Volovik,Y., Morris,T.S., Dharia,C., Das,K., Galperina,O., Gentz,R. and Arnold,E. (2002). "Structural basis of BLyS receptor recognition". Nat. Struct. Biol. 9: 288–292. doi:10.1038/nsb769. PMID 11862220. 

[edit] Further reading

  • Nardelli B, Moore PA, Li Y, Hilbert DM (2003). "B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases.". Leuk. Lymphoma 43 (7): 1367–73. PMID 12389615. 
  • Zhou T, Zhang J, Carter R, Kimberly R (2003). "BLyS and B cell autoimmunity.". Curr. Dir. Autoimmun. 6: 21–37. PMID 12408045. 
  • Stohl W (2005). "A therapeutic role for BLyS antagonists.". Lupus 13 (5): 317–22. PMID 15230285. 
  • Quartuccio L, Fabris M, Ferraccioli G (2004). "[B lymphocyte stimulator (BLyS) and monocytes: possible role in autoimmune diseases with a particular reference to rheumatoid arthritis]". Reumatismo 56 (3): 143–6. PMID 15470519. 
  • Sutherland AP, Mackay F, Mackay CR (2007). "Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas.". Pharmacol. Ther. 112 (3): 774–86. doi:10.1016/j.pharmthera.2006.06.002. PMID 16863659. 
  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling.". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324. 
  • Brink R (2007). "Regulation of B cell self-tolerance by BAFF.". Semin. Immunol. 18 (5): 276–83. doi:10.1016/j.smim.2006.04.003. PMID 16916609. 
  • Tangye SG, Bryant VL, Cuss AK, Good KL (2007). "BAFF, APRIL and human B cell disorders.". Semin. Immunol. 18 (5): 305–17. doi:10.1016/j.smim.2006.04.004. PMID 16916610. 
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470. 
  • Woodland RT, Schmidt MR, Thompson CB (2007). "BLyS and B cell homeostasis.". Semin. Immunol. 18 (5): 318–26. doi:10.1016/j.smim.2006.06.001. PMID 16931037. 
  • Kalled SL (2007). "Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production.". Semin. Immunol. 18 (5): 290–6. doi:10.1016/j.smim.2006.06.002. PMID 16931038. 
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039. 
  • Bosello S, Pers JO, Rochas C, et al. (2007). "BAFF and rheumatic autoimmune disorders: implications for disease management and therapy.". International journal of immunopathology and pharmacology 20 (1): 1–8. PMID 17346422. 
  • Shu HB, Hu WH, Johnson H (1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.". J. Leukoc. Biol. 65 (5): 680–3. PMID 10331498. 
  • Mukhopadhyay A, Ni J, Zhai Y, et al. (1999). "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.". J. Biol. Chem. 274 (23): 15978–81. PMID 10347144. 
  • Schneider P, MacKay F, Steiner V, et al. (1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.". J. Exp. Med. 189 (11): 1747–56. PMID 10359578. 
  • Moore PA, Belvedere O, Orr A, et al. (1999). "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.". Science 285 (5425): 260–3. PMID 10398604. 
  • Tribouley C, Wallroth M, Chan V, et al. (2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443–7. PMID 10661873. 
  • Gross JA, Johnston J, Mudri S, et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.". Nature 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128. 
  • Shu HB, Johnson H (2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMID 10908663. 

[edit] External links

 This article on a gene on chromosome 13 is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
v • d • e
Protein: glycoproteins
v • d • e
Cytokines: Tumor necrosis factors
Tumor necrosis factor (ligand) superfamily
4-1BB ligand - B-cell activating factor - FAS ligand - Lymphotoxin - OX40L - RANKL - TRAIL
Cluster of differentiation