CD49c

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Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), also known as ITGA3 and CD49c, is a human gene. ITGA3 is an integrin alpha subunit. It makes up half of the α3β1 integrin duplex.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[1]

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• MeSH CD49c+antigen

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