CD29
From Wikipedia, the free encyclopedia
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Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
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| Identifiers | ||||||||||||||
| Symbol(s) | ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB | |||||||||||||
| External IDs | OMIM: 135630 MGI: 96610 HomoloGene: 22999 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3688 | 16412 | ||||||||||||
| Ensembl | ENSG00000150093 | ENSMUSG00000025809 | ||||||||||||
| Uniprot | P05556 | Q3TIW5 | ||||||||||||
| Refseq | NM_002211 (mRNA) NP_002202 (protein) |
NM_010578 (mRNA) NP_034708 (protein) |
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| Location | Chr 10: 33.23 - 33.29 Mb | Chr 8: 131.59 - 131.62 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.[1]
[edit] References
[edit] Further reading
- Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". Bioessays 23 (7): 628–39. doi:. PMID 11462216.
- Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions.". Front. Biosci. 7: d219–27. PMID 11779688.
- Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more.". Cancer Metastasis Rev. 24 (3): 403–11. doi:. PMID 16258728.
[edit] External links
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