CD274
From Wikipedia, the free encyclopedia
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CD274 molecule
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| Identifiers | ||||||||||||||
| Symbol(s) | CD274; B7-H; B7H1; MGC142294; MGC142296; PD-L1; PDCD1L1; PDCD1LG1; PDL1 | |||||||||||||
| External IDs | OMIM: 605402 MGI: 1926446 HomoloGene: 8560 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 29126 | 60533 | ||||||||||||
| Ensembl | ENSG00000120217 | ENSMUSG00000016496 | ||||||||||||
| Uniprot | Q9NZQ7 | Q3U472 | ||||||||||||
| Refseq | NM_014143 (mRNA) NP_054862 (protein) |
NM_021893 (mRNA) NP_068693 (protein) |
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| Location | Chr 9: 5.44 - 5.46 Mb | Chr 19: 29.43 - 29.45 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD274 (Cluster of Differentiation 274) is a human protein encoded by the CD274 gene.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Tamura H, Ogata K, Dong H, Chen L (2004). "Immunology of B7-H1 and its roles in human diseases.". Int. J. Hematol. 78 (4): 321–8. PMID 14686489.
- Dong H, Zhu G, Tamada K, Chen L (1999). "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.". Nat. Med. 5 (12): 1365–9. doi:. PMID 10581077.
- Freeman GJ, Long AJ, Iwai Y, et al. (2000). "Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.". J. Exp. Med. 192 (7): 1027–34. PMID 11015443.
- Dong H, Strome SE, Salomao DR, et al. (2002). "Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.". Nat. Med. 8 (8): 793–800. doi:. PMID 12091876.
- Mazanet MM, Hughes CC (2002). "B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis.". J. Immunol. 169 (7): 3581–8. PMID 12244148.
- Trabattoni D, Saresella M, Biasin M, et al. (2003). "B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.". Blood 101 (7): 2514–20. doi:. PMID 12468426.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.". J. Immunol. 170 (3): 1257–66. PMID 12538684.
- Petroff MG, Chen L, Phillips TA, et al. (2003). "B7 family molecules are favorably positioned at the human maternal-fetal interface.". Biol. Reprod. 68 (5): 1496–504. doi:. PMID 12606489.
- Selenko-Gebauer N, Majdic O, Szekeres A, et al. (2003). "B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy.". J. Immunol. 170 (7): 3637–44. PMID 12646628.
- Curiel TJ, Wei S, Dong H, et al. (2003). "Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.". Nat. Med. 9 (5): 562–7. doi:. PMID 12704383.
- Wang S, Bajorath J, Flies DB, et al. (2003). "Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.". J. Exp. Med. 197 (9): 1083–91. doi:. PMID 12719480.
- Chen XL, Cao XD, Kang AJ, et al. (2003). "In situ expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma.". World J. Gastroenterol. 9 (6): 1370–3. PMID 12800259.
- Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1.". Biochem. Biophys. Res. Commun. 307 (3): 672–7. PMID 12893276.
- Wiendl H, Mitsdoerffer M, Schneider D, et al. (2003). "Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.". FASEB J. 17 (13): 1892–4. doi:. PMID 12923066.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Nakazawa A, Dotan I, Brimnes J, et al. (2004). "The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells.". Gastroenterology 126 (5): 1347–57. PMID 15131796.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:. PMID 15164053.
- Konishi J, Yamazaki K, Azuma M, et al. (2005). "B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression.". Clin. Cancer Res. 10 (15): 5094–100. doi:. PMID 15297412.
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