CD84
From Wikipedia, the free encyclopedia
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CD84 molecule
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| Identifiers | ||||||||||||||
| Symbol(s) | CD84; DKFZp781E2378; LY9B; SLAMF5; hCD84; mCD84 | |||||||||||||
| External IDs | OMIM: 604513 MGI: 1336885 HomoloGene: 48249 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8832 | 12523 | ||||||||||||
| Ensembl | ENSG00000066294 | ENSMUSG00000038147 | ||||||||||||
| Uniprot | Q9UIB8 | Q18PI6 | ||||||||||||
| Refseq | NM_003874 (mRNA) NP_003865 (protein) |
NM_013489 (mRNA) NP_038517 (protein) |
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| Location | Chr 1: 158.78 - 158.82 Mb | Chr 1: 173.68 - 173.72 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[1]
Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[supplied by OMIM][1]
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[edit] See also
[edit] References
[edit] Further reading
- Andreesen R, Bross KJ, Osterholz J, Emmrich F (1986). "Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens.". Blood 67 (5): 1257–64. PMID 3008886.
- Kingsmore SF, Souryal CA, Watson ML, et al. (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1.". Immunogenetics 42 (1): 59–62. PMID 7797269.
- de la Fuente MA, Pizcueta P, Nadal M, et al. (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily.". Blood 90 (6): 2398–405. PMID 9310491.
- Krause SW, Rehli M, Heinz S, et al. (2000). "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84.". Biochem. J. 346 Pt 3: 729–36. PMID 10698700.
- Palou E, Pirotto F, Solé J, et al. (2000). "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains.". Tissue Antigens 55 (2): 118–27. PMID 10746783.
- Lucas AD, Chadwick N, Warren BF, et al. (2001). "The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.". Am. J. Pathol. 158 (3): 855–66. PMID 11238035.
- Shlapatska LM, Mikhalap SV, Berdova AG, et al. (2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.". J. Immunol. 166 (9): 5480–7. PMID 11313386.
- Sayós J, Martín M, Chen A, et al. (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.". Blood 97 (12): 3867–74. PMID 11389028.
- Lewis J, Eiben LJ, Nelson DL, et al. (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.". Clin. Immunol. 100 (1): 15–23. doi:. PMID 11414741.
- Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:. PMID 11477068.
- Martin M, Romero X, de la Fuente MA, et al. (2001). "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.". J. Immunol. 167 (7): 3668–76. PMID 11564780.
- Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:. PMID 11689425.
- Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.". Eur. J. Immunol. 32 (6): 1640–9. doi:. PMID 12115647.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:. PMID 12621057.
- Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.". J. Immunol. 171 (5): 2485–95. PMID 12928397.
- Zaiss M, Hirtreiter C, Rehli M, et al. (2003). "CD84 expression on human hematopoietic progenitor cells.". Exp. Hematol. 31 (9): 798–805. PMID 12962726.
- Romero X, Benítez D, March S, et al. (2005). "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4).". Tissue Antigens 64 (2): 132–44. doi:. PMID 15245368.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Nanda N, Andre P, Bao M, et al. (2005). "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.". Blood 106 (9): 3028–34. doi:. PMID 16037392.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
