Neuropilin
From Wikipedia, the free encyclopedia
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neuropilin 1
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| Identifiers | |
| Symbol | NRP1 |
| Entrez | 8829 |
| HUGO | 8004 |
| OMIM | 602069 |
| RefSeq | NM_001024628 |
| UniProt | O14786 |
| Other data | |
| Locus | Chr. 10 p12 |
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neuropilin 2
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| Identifiers | |
| Symbol | NRP2 |
| Entrez | 8828 |
| HUGO | 8005 |
| OMIM | 602070 |
| RefSeq | NM_201279 |
| UniProt | O60462 |
| Other data | |
| Locus | Chr. 2 q34 |
Neuropilin is a protein receptor active in neurons.
[edit] Overview
There are two forms of Neuropilins, NRP-1 and NRP-2. They are transmembrane glycoproteins, and predominantly co-receptors for another class of proteins known as Semaphorins. Of the Semaphorins, NRP-1 and NRP-2 are specically receptors for Class-3 Semaphorins, which, amongst many things, are responsible for axon guidance during the development of the nervous system in vertebrates.
Neuropilins work as co-receptors as they have a very small cytoplasmic domain and thus rely upon other molecules to transduce their signals across a cell membrane, normally Plexins. Neuropilins generally work as dimers and different combinations have different affinities for molecules. For example, NRP-1 homodimers have high affinity for Sema-3A, whilst NRP-2 homodimers have high affinity for Sema-3F.
Another ligand for neuropilins is VEGF, a growth hormone involved in the regulation of angiogenesis.
[edit] External links
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