PDCD1LG2
From Wikipedia, the free encyclopedia
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Programmed cell death 1 ligand 2
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| Identifiers | ||||||||||||||
| Symbol(s) | PDCD1LG2; B7DC; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2; bA574F11.2 | |||||||||||||
| External IDs | OMIM: 605723 MGI: 1930125 HomoloGene: 10973 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 80380 | 58205 | ||||||||||||
| Ensembl | ENSG00000197646 | ENSMUSG00000016498 | ||||||||||||
| Uniprot | Q9BQ51 | Q3U304 | ||||||||||||
| Refseq | NM_025239 (mRNA) NP_079515 (protein) |
XM_993457 (mRNA) XP_998551 (protein) |
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| Location | Chr 9: 5.5 - 5.56 Mb | Chr 19: 29.48 - 29.54 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Programmed cell death 1 ligand 2, also known as PDCD1LG2, is a human gene.[1] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).
[edit] References
[edit] Further reading
- Latchman Y, Wood CR, Chernova T, et al. (2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation.". Nat. Immunol. 2 (3): 261–8. doi:. PMID 11224527.
- Tseng SY, Otsuji M, Gorski K, et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.". J. Exp. Med. 193 (7): 839–46. PMID 11283156.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.". J. Immunol. 170 (3): 1257–66. PMID 12538684.
- Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1.". Biochem. Biophys. Res. Commun. 307 (3): 672–7. PMID 12893276.
- Tsushima F, Iwai H, Otsuki N, et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses.". Eur. J. Immunol. 33 (10): 2773–82. doi:. PMID 14515261.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Aramaki O, Shirasugi N, Takayama T, et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.". Transplantation 77 (1): 6–12. doi:. PMID 14724428.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:. PMID 15164053.
- He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2.". Acta Biochim. Biophys. Sin. (Shanghai) 36 (4): 284–9. PMID 15253154.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Ohigashi Y, Sho M, Yamada Y, et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.". Clin. Cancer Res. 11 (8): 2947–53. doi:. PMID 15837746.
- Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion.". Eur. J. Immunol. 35 (12): 3561–9. doi:. PMID 16278812.
- Pfistershammer K, Klauser C, Pickl WF, et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation.". Eur. J. Immunol. 36 (5): 1104–13. doi:. PMID 16598819.
- Abelson AK, Johansson CM, Kozyrev SV, et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE.". Genes Immun. 8 (1): 69–74. doi:. PMID 17136123.
- Mataki N, Kikuchi K, Kawai T, et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases.". Am. J. Gastroenterol. 102 (2): 302–12. doi:. PMID 17311651.
- Wang SC, Lin CH, Ou TT, et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus.". J. Rheumatol. 34 (4): 721–5. PMID 17343323.
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