CD226
From Wikipedia, the free encyclopedia
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CD226 molecule
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| Identifiers | ||||||||||||||
| Symbol(s) | CD226; DNAM-1; DNAM1; PTA1; TLiSA1 | |||||||||||||
| External IDs | OMIM: 605397 MGI: 3039602 HomoloGene: 4787 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 10666 | 225825 | ||||||||||||
| Ensembl | ENSG00000150637 | ENSMUSG00000034028 | ||||||||||||
| Uniprot | Q15762 | Q5DW69 | ||||||||||||
| Refseq | NM_006566 (mRNA) NP_006557 (protein) |
NM_001039148 (mRNA) NP_001034237 (protein) |
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| Location | Chr 18: 65.68 - 65.78 Mb | Chr 18: 89.33 - 89.4 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD226 (Cluster of Differentiation 226) is a human protein encoded by the CD226 gene.[1]
CD226 is a ~65 kDa glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set and is encoded by a gene on human chromosome 18q22.3. CD226 mediates cellular adhesion to other cells bearing an unidentified ligand and cross-linking CD226 with antibodies causes cellular activation.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Shibuya A, Campbell D, Hannum C, et al. (1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.". Immunity 4 (6): 573–81. PMID 8673704.
- Shibuya K, Lanier LL, Phillips JH, et al. (2000). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.". Immunity 11 (5): 615–23. PMID 10591186.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Kojima H, Kanada H, Shimizu S, et al. (2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.". J. Biol. Chem. 278 (38): 36748–53. doi:. PMID 12847109.
- Bottino C, Castriconi R, Pende D, et al. (2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.". J. Exp. Med. 198 (4): 557–67. doi:. PMID 12913096.
- Shibuya K, Shirakawa J, Kameyama T, et al. (2004). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.". J. Exp. Med. 198 (12): 1829–39. doi:. PMID 14676297.
- Tahara-Hanaoka S, Shibuya K, Onoda Y, et al. (2005). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).". Int. Immunol. 16 (4): 533–8. PMID 15039383.
- Reymond N, Imbert AM, Devilard E, et al. (2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions.". J. Exp. Med. 199 (10): 1331–41. doi:. PMID 15136589.
- Ralston KJ, Hird SL, Zhang X, et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:. PMID 15138281.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Pende D, Spaggiari GM, Marcenaro S, et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).". Blood 105 (5): 2066–73. doi:. PMID 15536144.
- Pende D, Bottino C, Castriconi R, et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.". Mol. Immunol. 42 (4): 463–9. doi:. PMID 15607800.
- Tao D, Shangwu L, Qun W, et al. (2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.". J. Immunol. 174 (3): 1281–90. PMID 15661884.
- Ma D, Sun Y, Lin D, et al. (2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization.". Eur. J. Haematol. 74 (3): 228–40. doi:. PMID 15693793.
- Storojeva I, Boulay JL, Ballabeni P, et al. (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.". Oncology 68 (2-3): 246–55. doi:. PMID 16015041.
- Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.". J. Biol. Chem. 281 (37): 27190–6. doi:. PMID 16831868.
- Jian JL, Zhu CS, Xu ZW, et al. (2006). "Identification and characterization of the CD226 gene promoter.". J. Biol. Chem. 281 (39): 28731–6. doi:. PMID 16887814.
- Ye X, Zhang Z, Jiang Y, et al. (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients.". Viral Immunol. 19 (3): 576–81. doi:. PMID 16987076.
- El-Sherbiny YM, Meade JL, Holmes TD, et al. (2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.". Cancer Res. 67 (18): 8444–9. doi:. PMID 17875681.
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