ALCAM
From Wikipedia, the free encyclopedia
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Activated leukocyte cell adhesion molecule
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| Identifiers | ||||||||||||||
| Symbol(s) | ALCAM; CD166; FLJ38514; MEMD; MGC71733 | |||||||||||||
| External IDs | OMIM: 601662 MGI: 1313266 HomoloGene: 1229 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 214 | 11658 | ||||||||||||
| Ensembl | ENSG00000170017 | ENSMUSG00000022636 | ||||||||||||
| Uniprot | Q13740 | Q3TTY3 | ||||||||||||
| Refseq | NM_001627 (mRNA) NP_001618 (protein) |
NM_009655 (mRNA) NP_033785 (protein) |
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| Location | Chr 3: 106.57 - 106.78 Mb | Chr 16: 52.17 - 52.37 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Activated leukocyte cell adhesion molecule, also known as ALCAM, is a human gene.[1]. It is also called CD166 (cluster of differentiation 166).
[edit] References
[edit] Further reading
- Whitney GS, Starling GC, Bowen MA, et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.". J. Biol. Chem. 270 (31): 18187–90. PMID 7543097.
- Bowen MA, Patel DD, Li X, et al. (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.". J. Exp. Med. 181 (6): 2213–20. PMID 7760007.
- Bajorath J, Bowen MA, Aruffo A (1996). "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.". Protein Sci. 4 (8): 1644–7. PMID 8520490.
- Skonier JE, Bowen MA, Emswiler J, et al. (1996). "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.". Biochemistry 35 (38): 12287–91. doi:. PMID 8823162.
- Singer NG, Mitra R, Lialios F, et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.". Immunol. Lett. 58 (1): 9–14. PMID 9436462.
- Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).". Am. J. Pathol. 152 (3): 805–13. PMID 9502422.
- Cortés F, Deschaseaux F, Uchida N, et al. (1999). "HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues.". Blood 93 (3): 826–37. PMID 9920831.
- Tomita K, van Bokhoven A, Jansen CF, et al. (2000). "Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.". Biochem. Biophys. Res. Commun. 267 (3): 870–4. doi:. PMID 10673383.
- van Kempen LC, Nelissen JM, Degen WG, et al. (2001). "Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction.". J. Biol. Chem. 276 (28): 25783–90. doi:. PMID 11306570.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Kristiansen G, Pilarsky C, Wissmann C, et al. (2003). "ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions.". Prostate 54 (1): 34–43. doi:. PMID 12481253.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:. PMID 12754519.
- Fujiwara H, Tatsumi K, Kosaka K, et al. (2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166).". J. Clin. Endocrinol. Metab. 88 (7): 3437–43. PMID 12843199.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- van Kempen LC, Meier F, Egeblad M, et al. (2004). "Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis.". J. Invest. Dermatol. 122 (5): 1293–301. doi:. PMID 15140234.
- Zimmerman AW, Nelissen JM, van Emst-de Vries SE, et al. (2005). "Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.". J. Cell. Sci. 117 (Pt 13): 2841–52. doi:. PMID 15169840.
- Ikeda K, Quertermous T (2005). "Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.". J. Biol. Chem. 279 (53): 55315–23. doi:. PMID 15496415.
- Verma A, Shukla NK, Deo SV, et al. (2005). "MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma.". Oncology 68 (4-6): 462–70. doi:. PMID 16024937.
- Lunter PC, van Kilsdonk JW, van Beek H, et al. (2005). "Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity.". Cancer Res. 65 (19): 8801–8. doi:. PMID 16204050.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:. PMID 16335952.
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