CD81

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CD81 molecule
PDB rendering based on 1g8q.
Available structures: 1g8q, 1iv5
Identifiers
Symbol(s) CD81; S5.7; TAPA1; TSPAN28
External IDs OMIM: 186845 MGI: 1096398 HomoloGene: 20915
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 975 12520
Ensembl ENSG00000110651 ENSMUSG00000037706
Uniprot P60033 Q3UWG5
Refseq NM_004356 (mRNA)
NP_004347 (protein)		 XM_993688 (mRNA)
XP_998782 (protein)
Location Chr 11: 2.36 - 2.38 Mb Chr 7: 142.86 - 142.88 Mb
Pubmed search [1] [2]

CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a human gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CD81 CD81 molecule.

[edit] Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143-51. PMID 11739647. 
  • Ye J (2007). "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.". PLoS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMID 17784784. 
  • Bradbury LE, Kansas GS, Levy S, et al. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.". J. Immunol. 149 (9): 2841-50. PMID 1383329. 
  • Andria ML, Hsieh CL, Oren R, et al. (1991). "Genomic organization and chromosomal localization of the TAPA-1 gene.". J. Immunol. 147 (3): 1030-6. PMID 1650385. 
  • Oren R, Takahashi S, Doss C, et al. (1990). "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.". Mol. Cell. Biol. 10 (8): 4007-15. PMID 1695320. 
  • Levy S, Nguyen VQ, Andria ML, Takahashi S (1991). "Structure and membrane topology of TAPA-1.". J. Biol. Chem. 266 (22): 14597-602. PMID 1860863. 
  • Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.". J. Immunol. 145 (7): 2207-13. PMID 2398277. 
  • Matsumoto AK, Martin DR, Carter RH, et al. (1993). "Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.". J. Exp. Med. 178 (4): 1407-17. PMID 7690834. 
  • Nagira M, Imai T, Ishikawa I, et al. (1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression.". Cell. Immunol. 157 (1): 144-57. doi:10.1006/cimm.1994.1212. PMID 8039242. 
  • Virtaneva KI, Emi N, Marken JS, et al. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins.". Immunogenetics 39 (5): 329-34. PMID 8168850. 
  • Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma.". Biochem. Biophys. Res. Commun. 222 (1): 13-8. doi:10.1006/bbrc.1996.0690. PMID 8630057. 
  • Szöllósi J, Horejsí V, Bene L, et al. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.". J. Immunol. 157 (7): 2939-46. PMID 8816400. 
  • Berditchevski F, Tolias KF, Wong K, et al. (1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.". J. Biol. Chem. 272 (5): 2595-8. PMID 9006891. 
  • Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.". J. Biol. Chem. 272 (46): 29174-80. PMID 9360995. 
  • Tachibana I, Bodorova J, Berditchevski F, et al. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.". J. Biol. Chem. 272 (46): 29181-9. PMID 9360996. 
  • Hu RJ, Lee MP, Connors TD, et al. (1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.". Genomics 46 (1): 9-17. doi:10.1006/geno.1997.4981. PMID 9403053. 
  • Pileri P, Uematsu Y, Campagnoli S, et al. (1998). "Binding of hepatitis C virus to CD81.". Science 282 (5390): 938-41. PMID 9794763. 
  • Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 ( Pt 1): 103-11. PMID 10229664. 
  • Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.". J. Cell Biol. 146 (4): 893-904. PMID 10459022. 
  • Higginbottom A, Quinn ER, Kuo CC, et al. (2000). "Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2.". J. Virol. 74 (8): 3642-9. PMID 10729140. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350