ABCG2
From Wikipedia, the free encyclopedia
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ATP-binding cassette, sub-family G (WHITE), member 2
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| Identifiers | ||||||||||||||
| Symbol(s) | ABCG2; MRX; BCRP1; ABC15; ABCP; BCRP; BMDP; CDw338; EST157481; MGC102821; MXR; MXR1 | |||||||||||||
| External IDs | OMIM: 603756 MGI: 1347061 HomoloGene: 55852 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 9429 | 26357 | ||||||||||||
| Ensembl | ENSG00000118777 | ENSMUSG00000029802 | ||||||||||||
| Uniprot | Q9UNQ0 | Q7TMS5 | ||||||||||||
| Refseq | NM_004827 (mRNA) NP_004818 (protein) |
NM_011920 (mRNA) NP_036050 (protein) |
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| Location | Chr 4: 89.23 - 89.3 Mb | Chr 6: 58.53 - 58.62 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
ATP-binding cassette, sub-family G (WHITE), member 2, also known as ABCG2, is a human gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338).
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Abbott BL (2006). "ABCG2 (BCRP): a cytoprotectant in normal and malignant stem cells". Clin Adv Hematol Oncol. 4 (1): 63–72. PMID 16562373.
- Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism.". J. Lipid Res. 42 (10): 1513–20. PMID 11590207.
- Ejendal KF, Hrycyna CA (2003). "Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.". Curr. Protein Pept. Sci. 3 (5): 503–11. PMID 12369998.
- Doyle LA, Ross DD (2003). "Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).". Oncogene 22 (47): 7340–58. doi:. PMID 14576842.
- Sugimoto Y, Tsukahara S, Ishikawa E, Mitsuhashi J (2005). "Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.". Cancer Sci. 96 (8): 457–65. doi:. PMID 16108826.
- Ishikawa T, Tamura A, Saito H, et al. (2006). "Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.". Naturwissenschaften 92 (10): 451–63. doi:. PMID 16160819.
- Krishnamurthy P, Schuetz JD (2006). "Role of ABCG2/BCRP in biology and medicine.". Annu. Rev. Pharmacol. Toxicol. 46: 381–410. doi:. PMID 16402910.
- Robey RW, Polgar O, Deeken J, et al. (2007). "ABCG2: determining its relevance in clinical drug resistance.". Cancer Metastasis Rev. 26 (1): 39–57. doi:. PMID 17323127.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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