SLC22A18

From Wikipedia, the free encyclopedia

Solute carrier family 22 (organic cation transporter), member 18

Identifiers

SLC22A18; BWR1A; BWSCR1A; DKFZp667A184; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A

External IDs

OMIM: 602631 MGI: 1336884 HomoloGene: 1918

Gene ontology
Molecular Function:	• transporter activity • organic cation transmembrane transporter activity • symporter activity • tetracycline:hydrogen antiporter activity
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• ion transport • excretion • tetracycline transport • response to drug

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002555 (mRNA)
NP_002546 (protein)

NM_001042760 (mRNA)
NP_001036225 (protein)

Location

Chr 11: 2.88 - 2.9 Mb

Chr 7: 143.28 - 143.31 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (organic cation transporter), member 18, also known as SLC22A18, is a human gene.^[1]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18.

[edit] Further reading

Akiyama S (2002). "[Mechanisms of drug resistance and reversal of the resistance]". Hum. Cell 14 (4): 257-60. PMID 11925925.
Dao D, Frank D, Qian N, et al. (1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.". Hum. Mol. Genet. 7 (4): 597-608. PMID 9499412.
Schwienbacher C, Sabbioni S, Campi M, et al. (1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3873-8. PMID 9520460.
Cooper PR, Smilinich NJ, Day CD, et al. (1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.". Genomics 49 (1): 38-51. doi:10.1006/geno.1998.5221. PMID 9570947.
Reece M, Prawitt D, Landers J, et al. (1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules.". FEBS Lett. 433 (3): 245-50. PMID 9744804.
Lee MP, Reeves C, Schmitt A, et al. (1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.". Cancer Res. 58 (18): 4155-9. PMID 9751628.
Morisaki H, Hatada I, Morisaki T, Mukai T (1999). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.". DNA Res. 5 (4): 235-40. PMID 9802569.
Onyango P, Miller W, Lehoczky J, et al. (2001). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.". Genome Res. 10 (11): 1697-710. PMID 11076855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yamada HY, Gorbsky GJ (2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.". Oncogene 25 (9): 1330-9. doi:10.1038/sj.onc.1209167. PMID 16314844.
Gallagher E, Mc Goldrick A, Chung WY, et al. (2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer.". Genomics 88 (1): 12-7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)