GLUT2
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solute carrier family 2 (facilitated glucose transporter), member 2
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| Identifiers | |
| Symbol | SLC2A2 |
| Alt. Symbols | GLUT2 |
| Entrez | 6514 |
| HUGO | 11006 |
| OMIM | 138160 |
| RefSeq | NM_000340 |
| UniProt | P11168 |
| Other data | |
| Locus | Chr. 3 q26.2-q27 |
GLUT 2 is a transmembrane carrier protein and gene which is involved in passive glucose transport, especially the renal glucose reabsorption.
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[edit] Locations
It is found in cellular membranes of:
- liver
- pancreatic beta cells
- hypothalamus
- basolateral membrane of small intestine
- basolateral membrane of renal tubular cells
[edit] Function
It has high capacity but low affinity (high Km, ca. 5 mM) part of "the glucose sensor" in pancreatic β-cells. It is a very efficient carrier for glucose.
It may also carry glucosamine, suspected because mouse embryos lacking this glucose carrier protein/gene- and its suspected capacity to transport glucosamine- soon die. According to genetics researchers in neonatal and maternal-fetal medicine at Harvard University Medical School and Beth-Israel Deaconess Hospital Medical Center, this creates a problem for diabetic pregnancies in which glucose levels in the woman are uncontrolled, exposing her fetus to the possibility of neural tube and cardiac defects in the early-developing brain, spine, and heart.
[edit] See also
[edit] External links
- MeSH entry: Glucose Transporter Type 2
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