SLC1A1

From Wikipedia, the free encyclopedia

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Identifiers

SLC1A1; EAAC1; EAAT3

External IDs

OMIM: 133550 MGI: 105083 HomoloGene: 20881

Gene ontology
Molecular Function:	• symporter activity • glutamate:sodium symporter activity • sodium:dicarboxylate symporter activity
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• transport • dicarboxylic acid transport • synaptic transmission • glutamate transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004170 (mRNA)
NP_004161 (protein)

XM_001002136 (mRNA)
XP_001002136 (protein)

Location

Chr 9: 4.48 - 4.58 Mb

Chr 19: 28.9 - 28.98 Mb

Pubmed search

[1]

[2]

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1, also known as SLC1A1, is a human gene.^[1]

[edit] See also

[edit] References

^ Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1.

[edit] Further reading

Nieoullon A, Canolle B, Masmejean F, et al. (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850.
Arriza JL, Fairman WA, Wadiche JI, et al. (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.". J. Neurosci. 14 (9): 5559–69. PMID 7521911.
Shashidharan P, Huntley GW, Meyer T, et al. (1995). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.". Brain Res. 662 (1-2): 245–50. PMID 7859077.
Kanai Y, Stelzner M, Nussberger S, et al. (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198.
Smith CP, Weremowicz S, Kanai Y, et al. (1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders.". Genomics 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.
Zerangue N, Kavanaugh MP (1997). "Interaction of L-cysteine with a human excitatory amino acid transporter.". J. Physiol. (Lond.) 493 ( Pt 2): 419–23. PMID 8782106.
Bar-Peled O, Ben-Hur H, Biegon A, et al. (1997). "Distribution of glutamate transporter subtypes during human brain development.". J. Neurochem. 69 (6): 2571–80. PMID 9375691.
He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus.". J. Comp. Neurol. 418 (3): 255–69. PMID 10701825.
Lin CI, Orlov I, Ruggiero AM, et al. (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18.". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046.
Veenstra-VanderWeele J, Kim SJ, Gonen D, et al. (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder.". Mol. Psychiatry 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217.
Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1.". J. Neurosci. 23 (13): 5589–93. PMID 12843260.
Noorlander CW, de Graan PN, Nikkels PG, et al. (2004). "Distribution of glutamate transporters in the human placenta.". Placenta 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters.". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409.
Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, et al. (2006). "Increased expression and function of glutamate transporters in multiple sclerosis.". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2006). "GABA and glutamate transporters are expressed in human platelets.". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)