SLC5A1

From Wikipedia, the free encyclopedia

Solute carrier family 5 (sodium/glucose cotransporter), member 1

Identifiers

SLC5A1; D22S675; NAGT; SGLT1

External IDs

OMIM: 182380 MGI: 107678 HomoloGene: 55456

Gene ontology
Molecular Function:	• transporter activity • sugar:hydrogen ion symporter activity • glucose:sodium symporter activity • symporter activity • sodium ion binding
Cellular Component:	• integral to plasma membrane • brush border • membrane • apical plasma membrane
Biological Process:	• metanephros development • ion transport • sodium ion transport • glucose transport • intestinal absorption

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000343 (mRNA)
NP_000334 (protein)

NM_019810 (mRNA)
NP_062784 (protein)

Location

Chr 22: 30.77 - 30.84 Mb

Chr 5: 33.42 - 33.48 Mb

Pubmed search

[1]

[2]

Solute carrier family 5 (sodium/glucose cotransporter), member 1, also known as SLC5A1, is a human gene.^[1]

Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells. [supplied by OMIM]^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1.

[edit] Further reading

Wright EM, Loo DD, Panayotova-Heiermann M, et al. (1995). "'Active' sugar transport in eukaryotes.". J. Exp. Biol. 196: 197–212. PMID 7823022.
Wright EM, Turk E, Martin MG (2003). "Molecular basis for glucose-galactose malabsorption.". Cell Biochem. Biophys. 36 (2-3): 115–21. PMID 12139397.
Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. PMID 12488461.
Turk E, Zabel B, Mundlos S, et al. (1991). "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter.". Nature 350 (6316): 354–6. doi:10.1038/350354a0. PMID 2008213.
Hediger MA, Turk E, Wright EM (1989). "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5748–52. PMID 2490366.
Delézay O, Baghdiguian S, Fantini J (1995). "The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C.". J. Biol. Chem. 270 (21): 12536–41. PMID 7759499.
Turk E, Martín MG, Wright EM (1994). "Structure of the human Na+/glucose cotransporter gene SGLT1.". J. Biol. Chem. 269 (21): 15204–9. PMID 8195156.
Turk E, Klisak I, Bacallao R, et al. (1993). "Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1.". Genomics 17 (3): 752–4. doi:10.1006/geno.1993.1399. PMID 8244393.
Martín MG, Turk E, Lostao MP, et al. (1996). "Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption.". Nat. Genet. 12 (2): 216–20. doi:10.1038/ng0296-216. PMID 8563765.
Turk E, Kerner CJ, Lostao MP, Wright EM (1996). "Membrane topology of the human Na+/glucose cotransporter SGLT1.". J. Biol. Chem. 271 (4): 1925–34. PMID 8567640.
Lam JT, Martín MG, Turk E, et al. (1999). "Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects.". Biochim. Biophys. Acta 1453 (2): 297–303. PMID 10036327.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Obermeier S, Hüselweh B, Tinel H, et al. (2001). "Expression of glucose transporters in lactating human mammary gland epithelial cells.". European journal of nutrition 39 (5): 194–200. PMID 11131365.
Kasahara M, Maeda M, Hayashi S, et al. (2001). "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein.". Biochim. Biophys. Acta 1536 (2-3): 141–7. PMID 11406349.
Roll P, Massacrier A, Pereira S, et al. (2002). "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families.". Gene 285 (1-2): 141–8. PMID 12039040.
Ikari A, Nakano M, Kawano K, Suketa Y (2002). "Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70.". J. Biol. Chem. 277 (36): 33338–43. doi:10.1074/jbc.M200310200. PMID 12082088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)