SLCO1B3

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Solute carrier organic anion transporter family, member 1B3
Identifiers
Symbol(s) SLCO1B3; LST-3TM13; LST3; OATP1B3; OATP8; SLC21A8
External IDs OMIM: 605495 MGI: 1351899 HomoloGene: 75119
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 28234 28253
Ensembl ENSG00000111700 ENSMUSG00000030236
Uniprot Q9NPD5 Q9JJL3
Refseq NM_019844 (mRNA)
NP_062818 (protein)		 NM_020495 (mRNA)
NP_065241 (protein)
Location Chr 12: 20.86 - 20.96 Mb Chr 6: 141.59 - 141.65 Mb
Pubmed search [1] [2]

Solute carrier organic anion transporter family, member 1B3, also known as SLCO1B3, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3.

[edit] Further reading

  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507. 
  • Abe T, Unno M, Onogawa T, et al. (2001). "LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.". Gastroenterology 120 (7): 1689–99. PMID 11375950. 
  • Ismair MG, Stieger B, Cattori V, et al. (2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver.". Gastroenterology 121 (5): 1185–90. PMID 11677211. 
  • Jung D, Podvinec M, Meyer UA, et al. (2002). "Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.". Gastroenterology 122 (7): 1954–66. PMID 12055601. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cui Y, König J, Nies AT, et al. (2003). "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.". Lab. Invest. 83 (4): 527–38. PMID 12695556. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Vavricka SR, Jung D, Fried M, et al. (2004). "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.". J. Hepatol. 40 (2): 212–8. PMID 14739090. 
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). "Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.". J. Pharmacol. Exp. Ther. 311 (1): 139–46. doi:10.1124/jpet.104.068056. PMID 15159445. 
  • Letschert K, Keppler D, König J (2005). "Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).". Pharmacogenetics 14 (7): 441–52. PMID 15226676. 
  • Yamaguchi H, Okada M, Akitaya S, et al. (2006). "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.". J. Lipid Res. 47 (6): 1196–202. doi:10.1194/jlr.M500532-JLR200. PMID 16534140. 
  • Ohtsuka H, Abe T, Onogawa T, et al. (2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.". J. Gastroenterol. 41 (4): 369–77. doi:10.1007/s00535-006-1784-3. PMID 16741617. 
  • Briz O, Romero MR, Martinez-Becerra P, et al. (2006). "OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?". J. Biol. Chem. 281 (41): 30326–35. doi:10.1074/jbc.M602048200. PMID 16877380. 
  • Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). "Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.". Am. J. Physiol. Gastrointest. Liver Physiol. 293 (1): G271–8. doi:10.1152/ajpgi.00075.2007. PMID 17412826. 
  • Treiber A, Schneiter R, Häusler S, Stieger B (2007). "Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.". Drug Metab. Dispos. 35 (8): 1400–7. doi:10.1124/dmd.106.013615. PMID 17496208. 
  • Muto M, Onogawa T, Suzuki T, et al. (2007). "Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma.". Cancer Sci. 98 (10): 1570–6. doi:10.1111/j.1349-7006.2007.00570.x. PMID 17760952. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other