CD79A

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CD79a molecule, immunoglobulin-associated alpha
Identifiers
Symbol(s) CD79A; IGA; MB-1
External IDs OMIM: 112205 MGI: 101774 HomoloGene: 31053
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 973 12518
Ensembl ENSG00000105369 n/a
Uniprot P11912 n/a
Refseq NM_001783 (mRNA)
NP_001774 (protein)		 XM_989437 (mRNA)
XP_994531 (protein)
Location Chr 19: 47.07 - 47.08 Mb n/a
Pubmed search [1] [2]

CD79a molecule, immunoglobulin-associated alpha, also known as CD79A (Cluster of Differentiation 79A), is a human gene.[1]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha.

[edit] Further reading

  • Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006. 
  • Herren B, Burrows PD (2003). "B cell-restricted human mb-1 gene: expression, function, and lineage infidelity.". Immunol. Res. 26 (1-3): 35–43. PMID 12403343. 
  • Bastian A, Kratzin H, Eckart K, Hilschmann N (1993). "Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A.". Biol. Chem. Hoppe-Seyler 373 (12): 1255–63. PMID 1292512. 
  • Leduc I, Preud'homme JL, Cogné M (1992). "Structure and expression of the mb-1 transcript in human lymphoid cells.". Clin. Exp. Immunol. 90 (1): 141–6. PMID 1395095. 
  • Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing error frequency in the DNA sequence databases.". DNA Seq. 2 (6): 343–6. PMID 1446073. 
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. PMID 1534761. 
  • Ha HJ, Kubagawa H, Burrows PD (1992). "Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.". J. Immunol. 148 (5): 1526–31. PMID 1538135. 
  • Hutchcroft JE, Harrison ML, Geahlen RL (1992). "Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.". J. Biol. Chem. 267 (12): 8613–9. PMID 1569106. 
  • Flaswinkel H, Reth M (1992). "Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex.". Immunogenetics 36 (4): 266–9. PMID 1639443. 
  • Yu LM, Chang TW (1992). "Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes.". J. Immunol. 148 (2): 633–7. PMID 1729378. 
  • Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (1991). "The B-cell antigen receptor of the five immunoglobulin classes.". Nature 352 (6338): 777–81. doi:10.1038/352777a0. PMID 1881434. 
  • Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component.". J. Immunol. 147 (10): 3419–26. PMID 1940346. 
  • Sakaguchi N, Kashiwamura S, Kimoto M, et al. (1989). "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.". EMBO J. 7 (11): 3457–64. PMID 2463161. 
  • Grubb AO, López C, Tejler L, Mendez E (1984). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration.". J. Biol. Chem. 258 (23): 14698–707. PMID 6196366. 
  • Kurosaki T, Johnson SA, Pao L, et al. (1996). "Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.". J. Exp. Med. 182 (6): 1815–23. PMID 7500027. 
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. PMID 7512031. 
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. PMID 7514267. 
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335. 
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. PMID 7539038. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350