IL17RA

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Interleukin 17 receptor A
Identifiers
Symbol(s) IL17RA; CDw217; IL-17RA; IL17R; MGC10262; hIL-17R
External IDs OMIM: 605461 MGI: 107399 HomoloGene: 7378
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23765 16172
Ensembl ENSG00000177663 ENSMUSG00000002897
Uniprot Q96F46 Q60943
Refseq NM_014339 (mRNA)
NP_055154 (protein)		 NM_008359 (mRNA)
NP_032385 (protein)
Location Chr 22: 15.95 - 15.97 Mb Chr 6: 120.43 - 120.45 Mb
Pubmed search [1] [2]

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: IL17RA interleukin 17 receptor A.

[edit] Further reading

  • Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor.". Cytokine 9 (11): 794–800. PMID 9367539. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Honorati MC, Meliconi R, Pulsatelli L, et al. (2001). "High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients.". Rheumatology (Oxford) 40 (5): 522–7. PMID 11371660. 
  • Footz TK, Brinkman-Mills P, Banting GS, et al. (2001). "Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.". Genome Res. 11 (6): 1053–70. doi:10.1101/gr.154901. PMID 11381032. 
  • Haudenschild D, Moseley T, Rose L, Reddi AH (2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer.". J. Biol. Chem. 277 (6): 4309–16. doi:10.1074/jbc.M109372200. PMID 11706037. 
  • Kehlen A, Thiele K, Riemann D, Langner J (2002). "Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis.". Clin. Exp. Immunol. 127 (3): 539–46. PMID 11966773. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Steiner GE, Newman ME, Paikl D, et al. (2003). "Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate.". Prostate 56 (3): 171–82. doi:10.1002/pros.10238. PMID 12772186. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • McAllister F, Henry A, Kreindler JL, et al. (2005). "Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis.". J. Immunol. 175 (1): 404–12. PMID 15972674. 
  • Pongcharoen S, Niumsup P, Sanguansermsri D, et al. (2006). "The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells.". Am. J. Reprod. Immunol. 55 (4): 291–300. doi:10.1111/j.1600-0897.2006.00366.x. PMID 16533341. 
  • Toy D, Kugler D, Wolfson M, et al. (2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex.". J. Immunol. 177 (1): 36–9. PMID 16785495. 
  • Wang X, Dong Z, Zhu DD, Guan B (2006). "Expression profile of immune-associated genes in nasal polyps.". Ann. Otol. Rhinol. Laryngol. 115 (6): 450–6. PMID 16805377. 
  • Rong Z, Cheng L, Ren Y, et al. (2007). "Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6.". Cell. Signal. 19 (7): 1514–20. doi:10.1016/j.cellsig.2007.01.025. PMID 17346928. 
  • Maitra A, Shen F, Hanel W, et al. (2007). "Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression.". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7506–11. doi:10.1073/pnas.0611589104. PMID 17456598. 

[edit] External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350