Granulocyte macrophage colony-stimulating factor receptor
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Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
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| Identifiers | |||||||||||
| Symbol(s) | CSF2RA; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; MGC3848; MGC4838 | ||||||||||
| External IDs | OMIM: 306250 MGI: 1339754 HomoloGene: 48406 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 1438 | 12982 | |||||||||
| Ensembl | ENSG00000198223 | ENSMUSG00000059326 | |||||||||
| Uniprot | P15509 | Q00941 | |||||||||
| Refseq | XM_001133962 (mRNA) XP_001133962 (protein) |
XM_977426 (mRNA) XP_982520 (protein) |
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| Location | Chr X: 1.35 - 1.39 Mb | Chr 19: 61.28 - 61.28 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[1]
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[edit] Structure
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[3]
[edit] Signal transduction
Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.[4]
[edit] References
- ^ Nicola NA, Metcalf D (1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". J. Cell. Physiol. 124 (2): 313–21. doi:. PMID 3876343.
- ^ McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF (2003). "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex". Blood 101 (4): 1308–15. doi:. PMID 12393492.
- ^ a b Geijsen N, Koenderman L, Coffer PJ (2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine Growth Factor Rev. 12 (1): 19–25. doi:. PMID 11312115.
- ^ Doyle SE, Gasson JC (1998). "Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5". Blood 92 (3): 867–76. PMID 9680354.
[edit] Further reading
- Rappold G, Willson TA, Henke A, Gough NM (1992). "Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region.". Genomics 14 (2): 455–61. PMID 1358805.
- Hayashida K, Kitamura T, Gorman DM, et al. (1991). "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9655–9. PMID 1702217.
- Crosier KE, Wong GG, Mathey-Prevot B, et al. (1991). "A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7744–8. PMID 1715577.
- Raines MA, Liu L, Quan SG, et al. (1991). "Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8203–7. PMID 1832774.
- Gough NM, Gearing DP, Nicola NA, et al. (1990). "Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region.". Nature 345 (6277): 734–6. doi:. PMID 1972780.
- Ashworth A, Kraft A (1991). "Cloning of a potentially soluble receptor for human GM-CSF.". Nucleic Acids Res. 18 (23): 7178. PMID 2148207.
- Gearing DP, King JA, Gough NM, Nicola NA (1990). "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.". EMBO J. 8 (12): 3667–76. PMID 2555171.
- DiPersio J, Billing P, Kaufman S, et al. (1988). "Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.". J. Biol. Chem. 263 (4): 1834–41. PMID 2828352.
- Williams WV, VonFeldt JM, Rosenbaum H, et al. (1994). "Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution.". Arthritis Rheum. 37 (10): 1468–78. PMID 7945472.
- Jubinsky PT, Laurie AS, Nathan DG, et al. (1995). "Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit.". Blood 84 (12): 4174–85. PMID 7994031.
- Hu X, Emanuel PD, Zuckerman KS (1994). "Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.". Biochim. Biophys. Acta 1223 (2): 306–8. PMID 8086503.
- Nakagawa Y, Kosugi H, Miyajima A, et al. (1994). "Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily.". J. Biol. Chem. 269 (14): 10905–12. PMID 8144676.
- Zhao Y, Rong H, Chegini N (1996). "Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue.". Biol. Reprod. 53 (4): 923–30. PMID 8547489.
- Lia F, Rajotte D, Clark SC, Hoang T (1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex.". J. Biol. Chem. 271 (45): 28287–93. PMID 8910448.
- Wei S, Liu JH, Epling-Burnette PK, et al. (1996). "Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor.". J. Immunol. 157 (11): 5155–62. PMID 8943427.
- Soldi R, Primo L, Brizzi MF, et al. (1997). "Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor.". Blood 89 (3): 863–72. PMID 9028317.
- Matsuguchi T, Zhao Y, Lilly MB, Kraft AS (1997). "The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation.". J. Biol. Chem. 272 (28): 17450–9. PMID 9211889.
- Rivas CI, Vera JC, Delgado-López F, et al. (1998). "Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer.". Blood 91 (3): 1037–43. PMID 9446667.
- Hu X, Zuckerman KS (1998). "Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein.". Am. J. Hematol. 58 (2): 145–7. PMID 9625584.
- Taha RA, Leung DY, Ghaffar O, et al. (1998). "In vivo expression of cytokine receptor mRNA in atopic dermatitis.". J. Allergy Clin. Immunol. 102 (2): 245–50. PMID 9723668.
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