Erythropoietin receptor

Available structures: 1cn4, 1eba, 1ebp, 1eer, 1ern

Identifiers

EPOR; MGC138358

External IDs

Gene ontology
Molecular Function:	• erythropoietin receptor activity • guanyl-nucleotide exchange factor activity • protein binding
Cellular Component:	• intracellular • integral to plasma membrane • membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000121 (mRNA)
NP_000112 (protein)

XM_978769 (mRNA)
XP_983863 (protein)

Location

Pubmed search

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.^[1]

[edit] References

Zhu Y, D'Andrea AD (1999). "The molecular physiology of erythropoietin and the erythropoietin receptor.". Curr. Opin. Hematol. 1 (2): 113–8. PMID 9371269.
Lacombe C, Mayeux P (1998). "Biology of erythropoietin.". Haematologica 83 (8): 724–32. PMID 9793257.
Bonifacino JS (2002). "Quality control of receptor-kinase signaling complexes.". Dev. Cell 2 (1): 1–2. PMID 11782306.
Takeshita A, Shinjo K, Naito K, et al. (2003). "Erythropoietin receptor in myelodysplastic syndrome and leukemia.". Leuk. Lymphoma 43 (2): 261–4. PMID 11999556.
Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
Madeddu P, Emanueli C (2007). "Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor.". Circ. Res. 100 (5): 599–601. doi:10.1161/01.RES.0000261610.11754.b1. PMID 17363704.

v • d • e Transmembrane receptors: immune receptors

Cytokine receptor	Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2)

Pattern recognition/Toll-like	TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10

Fc receptor	ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal

Lymphocyte homing receptor	CD44 - L-selectin - VLA-4 - LFA-1

other	Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger

v • d • e Receptors: growth factor receptors

Neurotrophin receptors	Low affinity nerve growth factor receptor - high affinity (TrkA, TrkB, TrkC)

Somatomedin receptor	Insulin-like growth factor 1 receptor - Insulin-like growth factor 2 receptor

Other	Activin receptor (Type 1, Type 2) - Bone morphogenetic protein receptors - C-MET - CD117 - Erythropoietin receptor - Epidermal growth factor receptor - Fibroblast growth factor receptor - Platelet-derived growth factor receptor - TGF beta receptors - VEGF receptors (1, 2, 3)