From Wikipedia, the free encyclopedia
Interleukin-22 receptor is a type II cytokine receptor. It binds to Interleukin-22. It is a heterodimer of α1[1] and α2[2] subunits.
[edit] References
- ^ Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–9. doi:10.1074/jbc.M005304200. PMID 10875937.
- ^ Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511–6. doi:10.1073/pnas.171303198. PMID 11481447.
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Transmembrane receptors: immune receptors |
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| Cytokine receptor |
Type I: Interleukins ( 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors ( EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M, Leukemia inhibitory factor - common subunits ( Common gamma chain, common beta chain, CSF2RB)
Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ)
immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18
Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β
Chemokines: IL-8 (α, β), CCR1,CXCR4
Other: IL-17, TGF-beta ( 1, 2)
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| Pattern recognition/Toll-like |
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| Fc receptor |
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| Lymphocyte homing receptor |
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| other |
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