LAG3
From Wikipedia, the free encyclopedia
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Lymphocyte-activation gene 3
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| Identifiers | ||
| Symbol(s) | LAG3; CD223 | |
| External IDs | OMIM: 153337 MGI: 106588 HomoloGene: 1719 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 3902 | 16768 |
| Ensembl | ENSG00000089692 | ENSMUSG00000030124 |
| Uniprot | P18627 | Q61790 |
| Refseq | NM_002286 (mRNA) NP_002277 (protein) |
XM_981508 (mRNA) XP_986602 (protein) |
| Location | Chr 12: 6.75 - 6.76 Mb | Chr 6: 124.87 - 124.88 Mb |
| Pubmed search | [1] | [2] |
Lymphocyte-activation gene 3, also known as LAG3, is a human gene.[1] LAG3 has also recently been designated CD223 (cluster of differentiation 223).
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]
[edit] References
[edit] Further reading
- Triebel F (2004). "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination.". Trends Immunol. 24 (12): 619-22. PMID 14644131.
- Baixeras E, Huard B, Miossec C, et al. (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.". J. Exp. Med. 176 (2): 327-37. PMID 1380059.
- Triebel F, Jitsukawa S, Baixeras E, et al. (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4.". J. Exp. Med. 171 (5): 1393-405. PMID 1692078.
- Blum MD, Wong GT, Higgins KM, et al. (1993). "Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.". J. Exp. Med. 177 (5): 1343-58. PMID 8097522.
- Huard B, Mastrangeli R, Prigent P, et al. (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5744-9. PMID 9159144.
- Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus.". Immunogenetics 47 (1): 96-8. PMID 9382927.
- Bruniquel D, Borie N, Hannier S, Triebel F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II.". Immunogenetics 48 (2): 116-24. PMID 9634475.
- Hannier S, Tournier M, Bismuth G, Triebel F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.". J. Immunol. 161 (8): 4058-65. PMID 9780176.
- Hannier S, Triebel F (1999). "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes.". Int. Immunol. 11 (11): 1745-52. PMID 10545478.
- Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway.". Eur. J. Immunol. 31 (10): 2885-91. PMID 11592063.
- Andreae S, Piras F, Burdin N, Triebel F (2002). "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223).". J. Immunol. 168 (8): 3874-80. PMID 11937541.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Andreae S, Buisson S, Triebel F (2003). "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).". Blood 102 (6): 2130-7. doi:. PMID 12775570.
- Cai XF, Tao Z, Yan ZQ, et al. (2004). "Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family.". DNA Seq. 14 (2): 79-86. PMID 12825348.
- Gandhi MK, Lambley E, Duraiswamy J, et al. (2006). "Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients.". Blood 108 (7): 2280-9. doi:. PMID 16757686.
- Lundmark F, Harbo HF, Celius EG, et al. (2007). "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.". J. Neuroimmunol. 180 (1-2): 193-8. doi:. PMID 17020785.
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