MFI2
From Wikipedia, the free encyclopedia
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Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
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| Identifiers | ||||||||||||||
| Symbol(s) | MFI2; CD228; MAP97; MGC4856; MTF1 | |||||||||||||
| External IDs | OMIM: 155750 MGI: 1353421 HomoloGene: 4335 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4241 | 30060 | ||||||||||||
| Ensembl | ENSG00000163975 | ENSMUSG00000022780 | ||||||||||||
| Uniprot | P08582 | Q544J8 | ||||||||||||
| Refseq | NM_005929 (mRNA) NP_005920 (protein) |
NM_013900 (mRNA) NP_038928 (protein) |
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| Location | Chr 3: 198.21 - 198.24 Mb | Chr 16: 31.8 - 31.82 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5, also known as MFI2, is a human gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[1]
[edit] References
[edit] Further reading
- Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.". Oncogene 26 (42): 6113–24. doi:. PMID 17452986.
- Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site.". FEBS Lett. 298 (2-3): 215–8. PMID 1544447.
- Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.". FEBS Lett. 305 (1): 55–61. PMID 1633859.
- Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. PMID 2419904.
- Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.". J. Exp. Med. 169 (2): 585–90. PMID 2463331.
- Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study.". Liver 9 (2): 110–9. PMID 2540389.
- Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor.". Am. J. Hum. Genet. 38 (4): 540–8. PMID 3010712.
- Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen.". Hum. Genet. 72 (4): 294–6. PMID 3754536.
- Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.". Nature 303 (5912): 70–2. PMID 6843660.
- Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97.". EMBO J. 14 (17): 4178–86. PMID 7556058.
- Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.". J. Biol. Chem. 269 (4): 3034–40. PMID 8300636.
- Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium.". Brain Res. 712 (1): 117–21. PMID 8705293.
- Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.". Am. J. Pathol. 150 (6): 2143–52. PMID 9176405.
- Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.". Eur. J. Biochem. 267 (5): 1290–8. PMID 10691965.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:. PMID 11337467.
- Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1-3): 350–2. PMID 11852110.
- Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.". Eur. J. Biochem. 269 (18): 4435–45. PMID 12230555.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.". Exp. Mol. Pathol. 74 (2): 140–7. PMID 12710945.
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