PRDM2

From Wikipedia, the free encyclopedia


PR domain containing 2, with ZNF domain
Identifiers
Symbol(s) PRDM2; HUMHOXY1; MTB-ZF; RIZ; RIZ1; RIZ2
External IDs OMIM: 601196 MGI: 107628 HomoloGene: 40822
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7799 110593
Ensembl ENSG00000116731 ENSMUSG00000057637
Uniprot Q13029 n/a
Refseq NM_001007257 (mRNA)
NP_001007258 (protein)		 XM_898822 (mRNA)
XP_903915 (protein)
Location Chr 1: 13.9 - 14.02 Mb Chr 4: 142.4 - 142.45 Mb
Pubmed search [1] [2]

PR domain containing 2, with ZNF domain, also known as PRDM2, is a human gene.[1]

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain.

[edit] Further reading

  • Buyse IM, Shao G, Huang S (1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4467-71. PMID 7538672. 
  • Shapiro VS, Lee P, Winoto A (1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3.". Gene 163 (2): 329-30. PMID 7590293. 
  • Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene.". Eur. J. Biochem. 235 (3): 471-9. PMID 8654390. 
  • Buyse IM, Takahashi EI, Huang S (1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36.". Genomics 34 (1): 119-21. doi:10.1006/geno.1996.0249. PMID 8661032. 
  • Liu L, Shao G, Steele-Perkins G, Huang S (1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.". J. Biol. Chem. 272 (5): 2984-91. PMID 9006946. 
  • Xie M, Shao G, Buyse IM, Huang S (1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ.". J. Biol. Chem. 272 (42): 26360-6. PMID 9334209. 
  • He L, Yu JX, Liu L, et al. (1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.". Cancer Res. 58 (19): 4238-44. PMID 9766644. 
  • Abbondanza C, Medici N, Nigro V, et al. (2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3130-5. doi:10.1073/pnas.050015697. PMID 10706618. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800. 
  • Du Y, Carling T, Fang W, et al. (2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.". Cancer Res. 61 (22): 8094-9. PMID 11719434. 
  • Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia.". Tohoku J. Exp. Med. 196 (3): 193-201. PMID 12002276. 
  • Poetsch M, Dittberner T, Woenckhaus C (2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36.". Oncogene 21 (19): 3038-42. doi:10.1038/sj.onc.1205457. PMID 12082534. 
  • Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.". Br. J. Haematol. 119 (4): 940-8. PMID 12472571. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tokumaru Y, Nomoto S, Jerónimo C, et al. (2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer.". Oncogene 22 (44): 6954-8. doi:10.1038/sj.onc.1206403. PMID 14534544. 
  • Kim KC, Geng L, Huang S (2004). "Inactivation of a histone methyltransferase by mutations in human cancers.". Cancer Res. 63 (22): 7619-23. PMID 14633678. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Pan KF, Lu YY, Liu WG, et al. (2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability.". World J. Gastroenterol. 10 (18): 2719-22. PMID 15309726. 
  • Rossi M, Abbondanza C, D'Arcangelo A, et al. (2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation.". Cancer Lett. 215 (2): 229-37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642. 
  • Grundberg E, Carling T, Brändström H, et al. (2005). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.". J. Clin. Endocrinol. Metab. 89 (12): 6173-8. doi:10.1210/jc.2004-0403. PMID 15579774. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD