Thyroid transcription factor 1

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Thyroid transcription factor 1
PDB rendering based on 1ftt.
Available structures: 1ftt
Identifiers
Symbol(s) TITF1; BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; TTF-1; TTF1
External IDs OMIM: 600635 MGI: 108067 HomoloGene: 2488
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7080 21869
Ensembl ENSG00000136352 ENSMUSG00000001496
Uniprot P43699 Q6PFE0
Refseq NM_001079668 (mRNA)
NP_001073136 (protein)		 NM_009385 (mRNA)
NP_033411 (protein)
Location Chr 14: 36.06 - 36.06 Mb Chr 12: 57.45 - 57.45 Mb
Pubmed search [1] [2]

Thyroid transcription factor 1 (TITF1), also known as NK2 homeobox 1 (NKX2-1), is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TITF1 thyroid transcription factor 1.

[edit] Further reading

  • Lau SK, Luthringer DJ, Eisen RN (2002). "Thyroid transcription factor-1: a review.". Appl. Immunohistochem. Mol. Morphol. 10 (2): 97–102. PMID 12051643. 
  • Guazzi S, Price M, De Felice M, et al. (1990). "Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.". EMBO J. 9 (11): 3631–9. PMID 1976511. 
  • Oguchi H, Pan YT, Kimura S (1995). "The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein.". Biochim. Biophys. Acta 1261 (2): 304–6. PMID 7711079. 
  • Saiardi A, Tassi V, De Filippis V, Civitareale D (1995). "Cloning and sequence analysis of human thyroid transcription factor 1.". Biochim. Biophys. Acta 1261 (2): 307–10. PMID 7711080. 
  • Ikeda K, Clark JC, Shaw-White JR, et al. (1995). "Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells.". J. Biol. Chem. 270 (14): 8108–14. PMID 7713914. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Ghaffari M, Zeng X, Whitsett JA, Yan C (1998). "Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells.". Biochem. J. 328 ( Pt 3): 757–61. PMID 9396717. 
  • Hamdan H, Liu H, Li C, et al. (1998). "Structure of the human Nkx2.1 gene.". Biochim. Biophys. Acta 1396 (3): 336–48. PMID 9545595. 
  • Perrone L, Tell G, Di Lauro R (1999). "Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain.". J. Biol. Chem. 274 (8): 4640–5. PMID 9988700. 
  • Naltner A, Ghaffari M, Whitsett JA, Yan C (2000). "Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.". J. Biol. Chem. 275 (1): 56–62. PMID 10617585. 
  • Missero C, Pirro MT, Di Lauro R (2000). "Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1.". Mol. Cell. Biol. 20 (8): 2783–93. PMID 10733581. 
  • Naltner A, Wert S, Whitsett JA, Yan C (2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 279 (6): L1066–74. PMID 11076796. 
  • Yan C, Naltner A, Conkright J, Ghaffari M (2001). "Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells.". J. Biol. Chem. 276 (24): 21686–91. doi:10.1074/jbc.M011378200. PMID 11274148. 
  • Missero C, Pirro MT, Simeone S, et al. (2001). "The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription.". J. Biol. Chem. 276 (36): 33569–75. doi:10.1074/jbc.M104963200. PMID 11438542. 
  • Yi M, Tong GX, Murry B, Mendelson CR (2002). "Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1).". J. Biol. Chem. 277 (4): 2997–3005. doi:10.1074/jbc.M109793200. PMID 11713256. 
  • Liu C, Glasser SW, Wan H, Whitsett JA (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression.". J. Biol. Chem. 277 (6): 4519–25. doi:10.1074/jbc.M107585200. PMID 11733512. 
  • Ng WK, Chow JC, Ng PK (2002). "Thyroid transcription factor-1 is highly sensitive and specific in differentiating metastatic pulmonary from extrapulmonary adenocarcinoma in effusion fluid cytology specimens.". Cancer 96 (1): 43–8. PMID 11836702. 
  • Pohlenz J, Dumitrescu A, Zundel D, et al. (2002). "Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice.". J. Clin. Invest. 109 (4): 469–73. PMID 11854318. 
  • Krude H, Schütz B, Biebermann H, et al. (2002). "Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency.". J. Clin. Invest. 109 (4): 475–80. PMID 11854319. 
  • Miccadei S, De Leo R, Zammarchi E, et al. (2002). "The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay.". Mol. Endocrinol. 16 (4): 837–46. PMID 11923479. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD
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