GATA6

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GATA binding protein 6
Identifiers
Symbol(s) GATA6;
External IDs OMIM: 601656 MGI: 107516 HomoloGene: 68449
Orthologs
Human Mouse
Entrez 2627 14465
Ensembl ENSG00000141448 ENSMUSG00000005836
Uniprot Q92908 Q3UQJ2
Refseq NM_005257 (mRNA)
NP_005248 (protein)		 NM_010258 (mRNA)
NP_034388 (protein)
Location Chr 18: 18 - 18.04 Mb Chr 18: 11.05 - 11.09 Mb
Pubmed search [1] [2]

GATA binding protein 6, also known as GATA6, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: GATA6 GATA binding protein 6.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki E, Evans T, Lowry J, et al. (1997). "The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.". Genomics 38 (3): 283-90. doi:10.1006/geno.1996.0630. PMID 8975704. 
  • Huggon IC, Davies A, Gove C, et al. (1997). "Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut.". Biochim. Biophys. Acta 1353 (2): 98-102. PMID 9294001. 
  • Yoshida T, Sato R, Mahmood S, et al. (1997). "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.". FEBS Lett. 414 (2): 333-7. PMID 9315713. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Wada H, Hasegawa K, Morimoto T, et al. (2000). "A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene.". J. Biol. Chem. 275 (33): 25330-5. doi:10.1074/jbc.M000828200. PMID 10851229. 
  • Crawford SE, Qi C, Misra P, et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.". J. Biol. Chem. 277 (5): 3585-92. doi:10.1074/jbc.M107995200. PMID 11724781. 
  • Liu C, Glasser SW, Wan H, Whitsett JA (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression.". J. Biol. Chem. 277 (6): 4519-25. doi:10.1074/jbc.M107585200. PMID 11733512. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kiiveri S, Liu J, Westerholm-Ormio M, et al. (2003). "Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development.". Endocr. Res. 28 (4): 647-50. PMID 12530677. 
  • Chang DF, Belaguli NS, Iyer D, et al. (2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.". Dev. Cell 4 (1): 107-18. PMID 12530967. 
  • Nemer G, Nemer M (2003). "Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.". Dev. Biol. 254 (1): 131-48. PMID 12606287. 
  • Abe M, Hasegawa K, Wada H, et al. (2003). "GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.". Arterioscler. Thromb. Vasc. Biol. 23 (3): 404-10. doi:10.1161/01.ATV.0000059405.51042.A0. PMID 12615657. 
  • Ketola I, Toppari J, Vaskivuo T, et al. (2003). "Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis.". J. Clin. Endocrinol. Metab. 88 (4): 1858-65. PMID 12679484. 
  • Siltanen S, Heikkilä P, Bielinska M, et al. (2004). "Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas.". Pediatr. Res. 54 (4): 542-6. doi:10.1203/01.PDR.0000081295.56529.E9. PMID 12867597. 
  • Liu C, Ikegami M, Stahlman MT, et al. (2003). "Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (6): L1246-54. doi:10.1152/ajplung.00443.2002. PMID 12909592. 
  • Benchabane H, Wrana JL (2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.". Mol. Cell. Biol. 23 (18): 6646-61. PMID 12944489. 
  • Jimenez P, Saner K, Mayhew B, Rainey WE (2003). "GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis.". Endocrinology 144 (10): 4285-8. doi:10.1210/en.2003-0472. PMID 12959982. 
  • Saner KJ, Suzuki T, Sasano H, et al. (2005). "Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal.". Mol. Endocrinol. 19 (1): 184-97. doi:10.1210/me.2003-0332. PMID 15388788. 
  • Kiiveri S, Liu J, Heikkilä P, et al. (2005). "Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors.". Endocr. Res. 30 (4): 919-23. PMID 15666845. 

[edit] External links

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD