|
Transcription factors and intracellular receptors |
|
| (1) Basic domains |
|
|
Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH ( 1, 2) • BATF • BLZF1 • C/EBP ( α, β, γ, δ, ε, ζ) • CREB ( 1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF ( B, F, G, K) • NFE ( 2, L1, L2) • NRL • NRF1 • XBP1
|
|
(1.2) Basic helix-loop-helix ( bHLH)
|
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL ( ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND ( 1, 2) • HES ( 5, 6) • HEY ( 1, 2, L) • HES1 • HIF ( 1A, 3A) • ID ( 1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD ( 1, 2) • NPAS ( 1, 2, 3) • OLIG ( 1, 2) • Scleraxis • TAL1 • Twist • USF1
|
|
|
|
|
|
|
(1.6) Basic helix-span-helix (bHSH)
|
|
|
|
(2) Zinc finger
DNA-binding domains |
|
|
subfamily 1 ( Thyroid hormone ( α, β), CAR, FXR, LXR ( α, β), PPAR ( α, β/δ, γ), PXR, RAR ( α, β, γ), ROR ( α, β, γ), Rev-ErbA ( α, β), VDR) • subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( α, γ), PNR, RXR ( α, β, γ), Testicular receptor ( 2, 4), TLX) • subfamily 3 ( Steroid hormone ( Estrogen ( α, β), Estrogen related ( α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR ( NGFIB, NOR1, NURR1) • subfamily 5 ( LRH-1, SF1) • subfamily 6 ( GCNF) • subfamily 0 ( DAX1, SHP)
|
|
|
(2.2) Other Cys4
|
|
|
|
(2.3) Cys2His2
|
ATBF1 • BCL( 6, 11A, 11B) • CTCF • E4F1 • EGR ( 2, 3) • ERV3 • General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family ( 1, 2, 3, YY1) • HIC ( 1, 2) • HIVEP ( 1, 2, 3) • IKZF ( 1, 2, 3) • ILF ( 2, 3) • KLF ( 2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger (( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 ( 7A) • ZBT ( 16, 17, 33)
|
|
|
(2.4) Cys6
|
|
|
|
(2.5) Alternating composition
|
|
|
|
(3) Helix-turn-helix
domains |
|
|
ARX • CDX ( 1, 2) • CRX • CUTL1 • DLX ( 3, 4, 5) • EMX2 • EN ( 1, 2) • FHL ( 1, 2, 3) • HESX1 • HHEX • HLX • Homeobox ( A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS ( 1, 2) • MEOX2 • MNX1 • MSX ( 1, 2) • NANOG • NKX ( 2-1, 2-5, 3-1) • PHF ( 3, 6, 10, 17) • POU domain ( PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX ( 1, 2) • PDX1
|
|
|
(3.2) Paired box
|
|
|
|
|
E2F ( 1, 2, 3, 4, 5) • FOX proteins ( C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
|
|
|
|
|
|
|
(3.5) Tryptophan clusters
|
ELF ( 4, 5) • EGF • ELK ( 1, 3, 4) • ERF • ERG • ETS ( 1, 2) • ETV ( 1, 4, 5, 6) • FLI1 • Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
|
|
|
(3.6) TEA domain
|
transcriptional enhancer factor 1, 2
|
|
|
(4) β-Scaffold factors with
minor groove contacts |
|
(4.1) Rel homology region
|
|
|
|
|
|
|
|
(4.3) p53
|
|
|
|
|
|
|
|
|
HNF ( 1A, 1B) • LEF1 • SOX ( 2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
|
|
|
(4.10) Cold-shock domain
|
|
|
|
(4.11) Runt
|
|
|
|
(0) Other
transcription factors |
|
(0.2) HMGI(Y)
|
|
|
|
|
|
|
(0.5) AP-2/EREBP-related factors
|
|
|
|
(0.6) Miscellaneous
|
ARID ( 1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI ( 16, 35) • MLL ( 2, 3, T1) • MNDA • NFI ( A, B, C, X) • NFY ( A, B, C) • Rho/ Sigma • R-SMAD
|
|
|
