POU2F1

From Wikipedia, the free encyclopedia


POU domain, class 2, transcription factor 1
PDB rendering based on 1cqt.
Available structures: 1cqt, 1e3o, 1gt0, 1hf0, 1o4x, 1oct, 1pog, 1pou
Identifiers
Symbol(s) POU2F1; OCT1; OTF1
External IDs OMIM: 164175 MGI: 101898 HomoloGene: 37658
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5451 18986
Ensembl ENSG00000143190 ENSMUSG00000026565
Uniprot P14859 Q8C4C1
Refseq NM_002697 (mRNA)
NP_002688 (protein)		 NM_011137 (mRNA)
NP_035267 (protein)
Location Chr 1: 165.46 - 165.66 Mb Chr 1: 167.71 - 167.84 Mb
Pubmed search [1] [2]

POU domain, class 2, transcription factor 1, also known as POU2F1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1.

[edit] Further reading

  • Roberts SB, Segil N, Heintz N (1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle.". Science 253 (5023): 1022–6. PMID 1887216. 
  • Hsieh CL, Sturm R, Herr W, Francke U (1990). "The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1.". Genomics 6 (4): 666–72. PMID 2341156. 
  • Sturm RA, Das G, Herr W (1989). "The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.". Genes Dev. 2 (12A): 1582–99. PMID 2905684. 
  • Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.". J. Biol. Chem. 270 (33): 19613–23. PMID 7642649. 
  • Cox M, van Tilborg PJ, de Laat W, et al. (1995). "Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics.". J. Biomol. NMR 6 (1): 23–32. PMID 7663141. 
  • Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. PMID 7690421. 
  • Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.". EMBO J. 14 (6): 1198–208. PMID 7720710. 
  • Sturm RA, Eyre HJ, Baker E, Sutherland GR (1995). "The human OTF1 locus which overlaps the CD3Z gene is located at 1q22-->q23.". Cytogenet. Cell Genet. 68 (3-4): 231–2. PMID 7842742. 
  • Klemm JD, Rould MA, Aurora R, et al. (1994). "Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.". Cell 77 (1): 21–32. PMID 8156594. 
  • Zwilling S, Annweiler A, Wirth T (1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP.". Nucleic Acids Res. 22 (9): 1655–62. PMID 8202368. 
  • Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16).". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622. 
  • Assa-Munt N, Mortishire-Smith RJ, Aurora R, et al. (1993). "The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.". Cell 73 (1): 193–205. PMID 8462099. 
  • Dekker N, Cox M, Boelens R, et al. (1993). "Solution structure of the POU-specific DNA-binding domain of Oct-1.". Nature 362 (6423): 852–5. doi:10.1038/362852a0. PMID 8479524. 
  • Ström AC, Forsberg M, Lillhager P, Westin G (1996). "The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression.". Nucleic Acids Res. 24 (11): 1981–6. PMID 8668525. 
  • Inamoto S, Segil N, Pan ZQ, et al. (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.". J. Biol. Chem. 272 (47): 29852–8. PMID 9368058. 
  • Wong MW, Henry RW, Ma B, et al. (1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.". Mol. Cell. Biol. 18 (1): 368–77. PMID 9418884. 
  • Nie J, Sakamoto S, Song D, et al. (1998). "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase.". FEBS Lett. 424 (1-2): 27–32. PMID 9537509. 
  • Préfontaine GG, Lemieux ME, Giffin W, et al. (1998). "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.". Mol. Cell. Biol. 18 (6): 3416–30. PMID 9584182. 
  • La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16.". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMID 9889203. 
  • Kakizawa T, Miyamoto T, Ichikawa K, et al. (1999). "Functional interaction between Oct-1 and retinoid X receptor.". J. Biol. Chem. 274 (27): 19103–8. PMID 10383413. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD