MTA1

From Wikipedia, the free encyclopedia


Metastasis associated 1
PDB rendering based on 2crg.
Available structures: 2crg
Identifiers
Symbol(s) MTA1;
External IDs OMIM: 603526 MGI: 2150037 HomoloGene: 3442
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9112 116870
Ensembl ENSG00000182979 ENSMUSG00000021144
Uniprot Q13330 Q2KHS8
Refseq NM_004689 (mRNA)
NP_004680 (protein)		 NM_054081 (mRNA)
NP_473422 (protein)
Location Chr 14: 104.96 - 105.01 Mb Chr 12: 113.55 - 113.58 Mb
Pubmed search [1] [2]

Metastasis associated 1, also known as MTA1, is a human gene.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.[1]

[edit] References

  1. ^ Entrez Gene: MTA1 metastasis associated 1.

[edit] Further reading

  • Nicolson GL, Nawa A, Toh Y, et al. (2003). "Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation.". Clin. Exp. Metastasis 20 (1): 19-24. PMID 12650603. 
  • Toh Y, Pencil SD, Nicolson GL (1995). "Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines.". Gene 159 (1): 97-104. PMID 7607577. 
  • Toh Y, Pencil SD, Nicolson GL (1994). "A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.". J. Biol. Chem. 269 (37): 22958-63. PMID 8083195. 
  • Xue Y, Wong J, Moreno GT, et al. (1999). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.". Mol. Cell 2 (6): 851-61. PMID 9885572. 
  • Zhang Y, Ng HH, Erdjument-Bromage H, et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev. 13 (15): 1924-35. PMID 10444591. 
  • Toh Y, Kuninaka S, Endo K, et al. (2000). "Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1.". J. Exp. Clin. Cancer Res. 19 (1): 105-11. PMID 10840944. 
  • Nawa A, Nishimori K, Lin P, et al. (2000). "Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides.". J. Cell. Biochem. 79 (2): 202-12. PMID 10967548. 
  • Mazumdar A, Wang RA, Mishra SK, et al. (2001). "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.". Nat. Cell Biol. 3 (1): 30-7. doi:10.1038/35050532. PMID 11146623. 
  • Cui Q, Takiguchi S, Matsusue K, et al. (2001). "Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 93 (1-2): 139-40. PMID 11474200. 
  • Simpson A, Uitto J, Rodeck U, Mahoney MG (2001). "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.". Gene 273 (1): 29-39. PMID 11483358. 
  • Sasaki H, Moriyama S, Nakashima Y, et al. (2002). "Expression of the MTA1 mRNA in advanced lung cancer.". Lung Cancer 35 (2): 149-54. PMID 11804687. 
  • Mahoney MG, Simpson A, Jost M, et al. (2002). "Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes.". Oncogene 21 (14): 2161-70. doi:10.1038/sj.onc.1205277. PMID 11948399. 
  • Kumar R, Wang RA, Mazumdar A, et al. (2002). "A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.". Nature 418 (6898): 654-7. doi:10.1038/nature00889. PMID 12167865. 
  • Yan C, Wang H, Toh Y, Boyd DD (2003). "Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation.". J. Biol. Chem. 278 (4): 2309-16. doi:10.1074/jbc.M210369200. PMID 12431981. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234-9. doi:10.1074/jbc.M208992200. PMID 12493763. 
  • Talukder AH, Mishra SK, Mandal M, et al. (2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions.". J. Biol. Chem. 278 (13): 11676-85. doi:10.1074/jbc.M209570200. PMID 12527756. 
  • Mishra SK, Mazumdar A, Vadlamudi RK, et al. (2003). "MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions.". J. Biol. Chem. 278 (21): 19209-19. doi:10.1074/jbc.M301968200. PMID 12639951. 
  • Hamatsu T, Rikimaru T, Yamashita Y, et al. (2003). "The role of MTA1 gene expression in human hepatocellular carcinoma.". Oncol. Rep. 10 (3): 599-604. PMID 12684630. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD