FOXM1

From Wikipedia, the free encyclopedia


Forkhead box M1
Identifiers
Symbol(s) FOXM1; FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TRIDENT
External IDs OMIM: 602341 MGI: 1347487 HomoloGene: 7318
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2305 14235
Ensembl ENSG00000111206 ENSMUSG00000001517
Uniprot Q08050 Q6DI64
Refseq NM_021953 (mRNA)
NP_068772 (protein)		 NM_008021 (mRNA)
NP_032047 (protein)
Location Chr 12: 2.84 - 2.86 Mb Chr 6: 128.33 - 128.35 Mb
Pubmed search [1] [2]

Forkhead box M1, also known as FOXM1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: FOXM1 forkhead box M1.

[edit] Further reading

  • Bektas N, Haaf A, Veeck J, et al. (2008). "Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer.". BMC Cancer. 8 (42). doi:10.1186/1471-2407-8-42. PMID 18254960. 
  • Laoukili J, Stahl M, Medema RH (2007). "FoxM1: at the crossroads of ageing and cancer.". Biochim. Biophys. Acta 1775 (1): 92–102. doi:10.1016/j.bbcan.2006.08.006. PMID 17014965. 
  • Westendorf JM, Rao PN, Gerace L (1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.". Proc. Natl. Acad. Sci. U.S.A. 91 (2): 714–8. PMID 8290587. 
  • Ye H, Kelly TF, Samadani U, et al. (1997). "Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.". Mol. Cell. Biol. 17 (3): 1626–41. PMID 9032290. 
  • Yao KM, Sha M, Lu Z, Wong GG (1997). "Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.". J. Biol. Chem. 272 (32): 19827–36. PMID 9242644. 
  • Korver W, Roose J, Heinen K, et al. (1998). "The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.". Genomics 46 (3): 435–42. doi:10.1006/geno.1997.5065. PMID 9441747. 
  • Lüscher-Firzlaff JM, Westendorf JM, Zwicker J, et al. (1999). "Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation.". Oncogene 18 (41): 5620–30. doi:10.1038/sj.onc.1202967. PMID 10523841. 
  • Waris G, Siddiqui A (2002). "Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function.". J. Virol. 76 (6): 2721–9. PMID 11861839. 
  • Teh MT, Wong ST, Neill GW, et al. (2002). "FOXM1 is a downstream target of Gli1 in basal cell carcinomas.". Cancer Res. 62 (16): 4773–80. PMID 12183437. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wang X, Bhattacharyya D, Dennewitz MB, et al. (2004). "Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes.". Gene Expr. 11 (3-4): 149–62. PMID 14686788. 
  • Major ML, Lepe R, Costa RH (2004). "Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.". Mol. Cell. Biol. 24 (7): 2649–61. PMID 15024056. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Laoukili J, Kooistra MR, Brás A, et al. (2005). "FoxM1 is required for execution of the mitotic programme and chromosome stability.". Nat. Cell Biol. 7 (2): 126–36. doi:10.1038/ncb1217. PMID 15654331. 
  • Wonsey DR, Follettie MT (2005). "Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe.". Cancer Res. 65 (12): 5181–9. doi:10.1158/0008-5472.CAN-04-4059. PMID 15958562. 
  • Wang IC, Chen YJ, Hughes D, et al. (2006). "Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.". Mol. Cell. Biol. 25 (24): 10875–94. doi:10.1128/MCB.25.24.10875-10894.2005. PMID 16314512. 
  • Kim IM, Ackerson T, Ramakrishna S, et al. (2006). "The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer.". Cancer Res. 66 (4): 2153–61. doi:10.1158/0008-5472.CAN-05-3003. PMID 16489016. 
  • Lüscher-Firzlaff JM, Lilischkis R, Lüscher B (2006). "Regulation of the transcription factor FOXM1c by Cyclin E/CDK2.". FEBS Lett. 580 (7): 1716–22. doi:10.1016/j.febslet.2006.02.021. PMID 16504183. 
  • Liu M, Dai B, Kang SH, et al. (2006). "FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells.". Cancer Res. 66 (7): 3593–602. doi:10.1158/0008-5472.CAN-05-2912. PMID 16585184. 
  • Douard R, Moutereau S, Pernet P, et al. (2006). "Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer.". Surgery 139 (5): 665–70. doi:10.1016/j.surg.2005.10.012. PMID 16701100. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD