POU3F1

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POU domain, class 3, transcription factor 1
Identifiers
Symbol(s) POU3F1; OCT6; OTF6; SCIP
External IDs OMIM: 602479 MGI: 101896 HomoloGene: 20590
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5453 18991
Ensembl ENSG00000185668 n/a
Uniprot Q03052 n/a
Refseq NM_002699 (mRNA)
NP_002690 (protein)		 XM_980403 (mRNA)
XP_985497 (protein)
Location Chr 1: 38.28 - 38.29 Mb n/a
Pubmed search [1] [2]

POU domain, class 3, transcription factor 1, also known as POU3F1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: POU3F1 POU domain, class 3, transcription factor 1.

[edit] Further reading

  • Monuki ES, Kuhn R, Weinmaster G, et al. (1990). "Expression and activity of the POU transcription factor SCIP.". Science 249 (4974): 1300–3. PMID 1975954. 
  • Suzuki N, Rohdewohld H, Neuman T, et al. (1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.". EMBO J. 9 (11): 3723–32. PMID 1976514. 
  • Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.". EMBO J. 14 (6): 1198–208. PMID 7720710. 
  • Leger H, Sock E, Renner K, et al. (1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.". Mol. Cell. Biol. 15 (7): 3738–47. PMID 7791781. 
  • Faus I, Hsu HJ, Fuchs E (1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.". Mol. Cell. Biol. 14 (5): 3263–75. PMID 7909356. 
  • Tobler A, Schreiber E, Fontana A (1993). "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart.". Nucleic Acids Res. 21 (4): 1043. PMID 8451175. 
  • Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (1996). "Expression of transcription regulating genes in human preimplantation embryos.". Hum. Reprod. 10 (10): 2787–92. PMID 8567814. 
  • Jaegle M, Mandemakers W, Broos L, et al. (1996). "The POU factor Oct-6 and Schwann cell differentiation.". Science 273 (5274): 507–10. PMID 8662541. 
  • Sock E, Enderich J, Rosenfeld MG, Wegner M (1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.". J. Biol. Chem. 271 (29): 17512–8. PMID 8663425. 
  • Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.". Brain Res. Mol. Brain Res. 45 (1): 99–107. PMID 9105675. 
  • Sumiyama K, Washio-Watanabe K, Ono T, et al. (1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.". Mamm. Genome 9 (2): 180–1. PMID 9457692. 
  • Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.". J. Neurosci. 18 (19): 7891–902. PMID 9742157. 
  • Kawasaki T, Oka N, Tachibana H, et al. (2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies.". Acta Neuropathol. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. PMID 12557005. 
  • Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013. 
  • Ryu EJ, Wang JY, Le N, et al. (2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.". J. Neurosci. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMID 17959798. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD