FHL2

From Wikipedia, the free encyclopedia


Four and a half LIM domains 2
PDB rendering based on 1x4k.
Available structures: 1x4k, 1x4l, 2d8z
Identifiers
Symbol(s) FHL2; AAG11; DRAL; SLIM3
External IDs OMIM: 602633 MGI: 1338762 HomoloGene: 20372
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2274 14200
Ensembl ENSG00000115641 ENSMUSG00000008136
Uniprot Q14192 Q543D7
Refseq NM_001039492 (mRNA)
NP_001034581 (protein)		 NM_010212 (mRNA)
NP_034342 (protein)
Location Chr 2: 105.34 - 105.42 Mb Chr 1: 43.07 - 43.14 Mb
Pubmed search [1] [2]

Four and a half LIM domains 2, also known as FHL2, is a human gene.

LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: FHL2 four and a half LIM domains 2.

[edit] Further reading

  • Morgan MJ, Madgwick AJ (1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle.". Biochem. Biophys. Res. Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  • Genini M, Schwalbe P, Scholl FA, et al. (1997). "Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma.". DNA Cell Biol. 16 (4): 433–42. PMID 9150430. 
  • Chan KK, Tsui SK, Lee SM, et al. (1998). "Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.". Gene 210 (2): 345–50. PMID 9573400. 
  • Chan KK, Tsui SK, Ngai SM, et al. (2000). "Protein-protein interaction of FHL2, a LIM domain protein preferentially expressed in human heart, with hCDC47.". J. Cell. Biochem. 76 (3): 499–508. PMID 10649446. 
  • Müller JM, Isele U, Metzger E, et al. (2000). "FHL2, a novel tissue-specific coactivator of the androgen receptor.". EMBO J. 19 (3): 359–69. doi:10.1093/emboj/19.3.359. PMID 10654935. 
  • Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324. 
  • Tanahashi H, Tabira T (2001). "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.". Hum. Mol. Genet. 9 (15): 2281–9. PMID 11001931. 
  • Fimia GM, De Cesare D, Sassone-Corsi P (2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.". Mol. Cell. Biol. 20 (22): 8613–22. PMID 11046156. 
  • Scholl FA, McLoughlin P, Ehler E, et al. (2000). "DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis.". J. Cell Biol. 151 (3): 495–506. PMID 11062252. 
  • Li HY, Kotaka M, Kostin S, et al. (2001). "Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization.". Cell Motil. Cytoskeleton 48 (1): 11–23. doi:10.1002/1097-0169(200101)48:1<11::AID-CM2>3.0.CO;2-I. PMID 11124707. 
  • Li HY, Ng EK, Lee SM, et al. (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET).". J. Cell. Biochem. 80 (3): 293–303. PMID 11135358. 
  • Dye BT, Patton JG (2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles.". Exp. Cell Res. 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID 11161712. 
  • Ng EK, Chan KK, Wong CH, et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.". J. Cell. Biochem. 84 (3): 556–66. PMID 11813260. 
  • Amaar YG, Thompson GR, Linkhart TA, et al. (2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2).". J. Biol. Chem. 277 (14): 12053–60. doi:10.1074/jbc.M110872200. PMID 11821401. 
  • Stilo R, Leonardi A, Formisano L, et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.". FEBS Lett. 521 (1-3): 165–9. PMID 12067710. 
  • McLoughlin P, Ehler E, Carlile G, et al. (2002). "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.". J. Biol. Chem. 277 (40): 37045–53. doi:10.1074/jbc.M203336200. PMID 12145280. 
  • Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. PMID 12358155. 
  • Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". EMBO J. 21 (21): 5775–86. PMID 12411495. 
  • Lange S, Auerbach D, McLoughlin P, et al. (2003). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.". J. Cell. Sci. 115 (Pt 24): 4925–36. PMID 12432079. 
  • Wei Y, Renard CA, Labalette C, et al. (2003). "Identification of the LIM protein FHL2 as a coactivator of beta-catenin.". J. Biol. Chem. 278 (7): 5188–94. doi:10.1074/jbc.M207216200. PMID 12466281. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD