COUP-TFI

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Nuclear receptor subfamily 2, group F, member 1
Identifiers
Symbol(s) NR2F1; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1
External IDs OMIM: 132890 MGI: 1352451 HomoloGene: 21158
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7025 13865
Ensembl ENSG00000175745 ENSMUSG00000069171
Uniprot P10589 Q32NY6
Refseq NM_005654 (mRNA)
NP_005645 (protein)		 XM_980546 (mRNA)
XP_985640 (protein)
Location Chr 5: 92.94 - 92.96 Mb Chr 13: 78.65 - 78.66 Mb
Pubmed search [1] [2]

COUP-TFI (COUP transcription factor 1), also known as NR2F1 (nuclear receptor subfamily 2, group F, member 1) is a human protein encoded by the NR2F1 gene.[1]

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter)) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. It interacts with COPS2.


[edit] References

  1. ^ Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1.

[edit] Further reading

  • Kliewer SA, Umesono K, Heyman RA, et al. (1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1448–52. PMID 1311101. 
  • Berrodin TJ, Marks MS, Ozato K, et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.". Mol. Endocrinol. 6 (9): 1468–78. PMID 1331778. 
  • Ing NH, Beekman JM, Tsai SY, et al. (1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).". J. Biol. Chem. 267 (25): 17617–23. PMID 1517211. 
  • Wang LH, Tsai SY, Cook RG, et al. (1989). "COUP transcription factor is a member of the steroid receptor superfamily.". Nature 340 (6229): 163–6. doi:10.1038/340163a0. PMID 2739739. 
  • Miyajima N, Kadowaki Y, Fukushige S, et al. (1989). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.". Nucleic Acids Res. 16 (23): 11057–74. PMID 2905047. 
  • Qiu Y, Krishnan V, Zeng Z, et al. (1996). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.". Genomics 29 (1): 240–6. PMID 8530078. 
  • Sawaya BE, Rohr O, Aunis D, Schaeffer E (1996). "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells.". J. Biol. Chem. 271 (38): 23572–6. PMID 8798567. 
  • Rohr O, Aunis D, Schaeffer E (1998). "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells.". J. Biol. Chem. 272 (49): 31149–55. PMID 9388268. 
  • Dressel U, Thormeyer D, Altincicek B, et al. (1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.". Mol. Cell. Biol. 19 (5): 3383–94. PMID 10207062. 
  • Klinge CM, Kaur K, Swanson HI (2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.". Arch. Biochem. Biophys. 373 (1): 163–74. doi:10.1006/abbi.1999.1552. PMID 10620335. 
  • Rohr O, Schwartz C, Hery C, et al. (2000). "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells.". J. Biol. Chem. 275 (4): 2654–60. PMID 10644726. 
  • Sugiyama T, Wang JC, Scott DK, Granner DK (2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.". J. Biol. Chem. 275 (5): 3446–54. PMID 10652338. 
  • Vlahou A, Flytzanis CN (2000). "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle.". Dev. Biol. 218 (2): 284–98. doi:10.1006/dbio.1999.9456. PMID 10656770. 
  • Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.". J. Biol. Chem. 275 (14): 10315–22. PMID 10744719. 
  • Gay F, Anglade I, Gong Z, Salbert G (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions.". Mol. Endocrinol. 14 (10): 1627–48. PMID 11043578. 
  • You M, Fischer M, Cho WK, Crabb D (2002). "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors.". Arch. Biochem. Biophys. 398 (1): 79–86. doi:10.1006/abbi.2001.2713. PMID 11811951. 
  • Lin F, Kolluri SK, Chen GQ, Zhang XK (2002). "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.". J. Biol. Chem. 277 (24): 21414–22. doi:10.1074/jbc.M201885200. PMID 11934895. 
  • Métivier R, Gay FA, Hübner MR, et al. (2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMID 12093745. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yu X, Mertz JE (2003). "Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1.". J. Virol. 77 (4): 2489–99. PMID 12551987. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD