ETV4

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Ets variant gene 4 (E1A enhancer binding protein, E1AF)
Identifiers
Symbol(s) ETV4; E1A-F; E1AF; PEA3; PEAS3
External IDs OMIM: 600711 MGI: 99423 HomoloGene: 1504
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2118 18612
Ensembl ENSG00000175832 ENSMUSG00000017724
Uniprot P43268 Q3UMZ6
Refseq NM_001079675 (mRNA)
NP_001073143 (protein)		 NM_008815 (mRNA)
NP_032841 (protein)
Location Chr 17: 38.96 - 38.98 Mb Chr 11: 101.59 - 101.6 Mb
Pubmed search [1] [2]

Ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as ETV4, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF).

[edit] Further reading

  • Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.". Genomics 25 (1): 256–63. PMID 7774926. 
  • Liu SH, Peng BH, Ma JT, et al. (1995). "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor.". Dev. Genet. 16 (3): 229–40. doi:10.1002/dvg.1020160303. PMID 7796532. 
  • Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "The search for BRCA1.". Cancer Res. 54 (24): 6374–82. PMID 7987831. 
  • Higashino F, Yoshida K, Fujinaga Y, et al. (1993). "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.". Nucleic Acids Res. 21 (3): 547–53. PMID 8441666. 
  • Isobe M, Yamagishi F, Yoshida K, et al. (1996). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21.". Genomics 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053. 
  • Urano F, Umezawa A, Hong W, et al. (1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma.". Biochem. Biophys. Res. Commun. 219 (2): 608–12. PMID 8605035. 
  • Coutte L, Monté D, Baert J, de Launoit Y (2000). "Genomic organization of the human e1af gene,a member of Ets transcription factors.". Gene 240 (1): 201–7. PMID 10564827. 
  • Mastrangelo T, Modena P, Tornielli S, et al. (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor.". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Davidson B, Goldberg I, Gotlieb WH, et al. (2004). "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma.". Clin. Cancer Res. 9 (4): 1412–9. PMID 12684413. 
  • Span PN, Manders P, Heuvel JJ, et al. (2004). "E1AF expression levels are not associated with prognosis in human breast cancer.". Breast Cancer Res. Treat. 79 (1): 129–31. PMID 12779089. 
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
  • Liu Y, Borchert GL, Phang JM (2004). "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells.". J. Biol. Chem. 279 (18): 18694–700. doi:10.1074/jbc.M308136200. PMID 14976201. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Davidson B, Goldberg I, Tell L, et al. (2004). "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions.". Clin. Exp. Metastasis 21 (3): 191–9. PMID 15387369. 
  • Fauquette V, Perrais M, Cerulis S, et al. (2005). "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells.". Biochem. J. 386 (Pt 1): 35–45. doi:10.1042/BJ20040706. PMID 15461591. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zhu X, Jiang J, Shen H, et al. (2005). "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.". J. Biol. Chem. 280 (13): 12503–16. doi:10.1074/jbc.M413631200. PMID 15611127. 
  • Takahashi A, Higashino F, Aoyagi M, et al. (2005). "E1AF degradation by a ubiquitin-proteasome pathway.". Biochem. Biophys. Res. Commun. 327 (2): 575–80. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152. 
  • Nosho K, Yoshida M, Yamamoto H, et al. (2005). "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.". Carcinogenesis 26 (5): 892–9. doi:10.1093/carcin/bgi029. PMID 15695237. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD