MEF2D

From Wikipedia, the free encyclopedia


MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)
PDB rendering based on 1c7u.
Available structures: 1c7u, 1egw
Identifiers
Symbol(s) MEF2D; DKFZp686I1536
External IDs OMIM: 600663 MGI: 99533 HomoloGene: 4327
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4209 17261
Ensembl ENSG00000116604 ENSMUSG00000001419
Uniprot Q14814 Q3URR2
Refseq NM_005920 (mRNA)
NP_005911 (protein)		 XM_987375 (mRNA)
XP_992469 (protein)
Location Chr 1: 154.7 - 154.74 Mb Chr 3: 88.23 - 88.25 Mb
Pubmed search [1] [2]

MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D), also known as MEF2D, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D).

[edit] Further reading

  • Breitbart RE, Liang CS, Smoot LB, et al. (1994). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.". Development 118 (4): 1095–106. PMID 8269842. 
  • Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763. 
  • Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells.". J. Biol. Chem. 271 (40): 24927–33. PMID 8798771. 
  • Yang CC, Ornatsky OI, McDermott JC, et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.". Nucleic Acids Res. 26 (20): 4771–7. PMID 9753748. 
  • Zhao M, New L, Kravchenko VV, et al. (1999). "Regulation of the MEF2 family of transcription factors by p38.". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528. 
  • Wang AH, Bertos NR, Vezmar M, et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.". Mol. Cell. Biol. 19 (11): 7816–27. PMID 10523670. 
  • Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. doi:10.1073/pnas.080064097. PMID 10737771. 
  • Kato Y, Zhao M, Morikawa A, et al. (2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.". J. Biol. Chem. 275 (24): 18534–40. doi:10.1074/jbc.M001573200. PMID 10849446. 
  • Youn HD, Chatila TA, Liu JO (2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.". EMBO J. 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. PMID 10944115. 
  • Slepak TI, Webster KA, Zang J, et al. (2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D.". J. Biol. Chem. 276 (10): 7575–85. doi:10.1074/jbc.M004625200. PMID 11096067. 
  • Choi SJ, Park SY, Han TH (2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation.". Nucleic Acids Res. 29 (13): 2836–42. PMID 11433030. 
  • Okamoto S, Li Z, Ju C, et al. (2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3974–9. doi:10.1073/pnas.022036399. PMID 11904443. 
  • Park SY, Shin HM, Han TH (2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter.". Mol. Immunol. 39 (1-2): 25–30. PMID 12213324. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Linseman DA, Bartley CM, Le SS, et al. (2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.". J. Biol. Chem. 278 (42): 41472–81. doi:10.1074/jbc.M307245200. PMID 12896970. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Grégoire S, Yang XJ (2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.". Mol. Cell. Biol. 25 (6): 2273–87. doi:10.1128/MCB.25.6.2273-2287.2005. PMID 15743823. 
  • Prima V, Gore L, Caires A, et al. (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.". Leukemia 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID 15744350. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD